Anti-Human CLDN4 Recombinant Antibody (cKM3900)
CAT#: TAB-502LC
Recombinant monoclonal antibody to CLDN4. cKM3900 is a chimeric anitbody (mouse/human) that can be potentially used in the treatment of pancreatic cancer .
Published Data
Gene Expression
FC
Figure 1 shows results in which the reactivity of an anti-CLDN4 monoclonal antibody KM3900 for CLDN4-myc/His gene-introduced CHO cell (CLDN4/CHO) and vector-introduced CHO cell (Vector/CHO) was measured by ABI 8200. The ordinate shows fluorescence intensity.
FC
Figure 2 shows results in which the reactivity of an anti-CLDN4 monoclonal antibody KM3900 for CLDN4-myc/His gene-introduced CHO cell (CLDN4/CHO) and vector-introduced CHO cell (Vector/C10C) was measured by FCM. The ordinate shows the number of cells, and the abscissa shows fluorescence intensity.
WB
Figure 3 shows the reactivity of an anti-CLDN4 monoclonal antibody KM3900 by Western blotting.
FC
Figure 4 shows results in which the reactivity of a negative control antibody mouse IgG2a and anti-CLDN4 monoclonal antibodies KM3900 and KM3907 for human cancer cell lines, MCF7 (breast cancer), HT-29 (colorectal cancer), SW480 (colorectal cancer), 22Rv1 (prostate cancer), DU 145 prostate cancer) and PC-3 (prostate cancer), was measured by FCM.
Cyt
Figure 5 shows results in which the ADCC activity of an anti-CLDN4 human chimeric antibody cKM3900.
Cyt
Figure 6 shows results in which the CDC activity of an anti-CLDN4 human chimeric antibody cKM3900 for CLDN4-myc/His gene-introduced CHO cell (CLDN4/CHO) was measured. The ordinate shows CDC activity (%), and the abscissa shows the antibody concentration.
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Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_B_7_5.jpg
Normal Tissue
Figure 3 Esophagus
Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_B_6_1.jpg
Normal Tissue
Figure 4 High expression in colon.
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, BEWO, CAPAN-2, MCF7, OE19, PC-3, RT4, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000189143-CLDN4
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Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Clone
- cKM3900
- Applications
- Cyt, FC, WB
- Related Disease
- Pancreatic cancer
Product Property
- Preservative
- Human
- Storage
- CLDN4 (claudin 4)
Applications
- Application Notes
- This antibody has been reported for use in Cytotoxicity, Flow Cytometry, Western Blot.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone cKM3900"
- CAT
- Product Name
See other products for "CLDN4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3288z | Mouse Anti-CLDN4 Recombinant Antibody (clone 38H5) | IHC, IF, WB | Mouse IgG1 |
| ZG-0161J | Mouse Anti-CLDN4 Recombinant Antibody (ZG-0161J) | IHC-P, IF | Mouse IgG |
| VS3-CJ119 | Mouse Anti-CLDN4 Recombinant Antibody (clone ABT-CLD4) | WB, IHC-P | Mouse IgG2b, κ |
| VS3-CJ120 | Mouse Anti-CLDN4 Recombinant Antibody (clone PT1925) | WB, IHC-P | Mouse IgG2b, κ |
| VS3-FY392 | Recombinant Mouse Anti-CLDN4 Antibody (clone 4A10-7F7-4D8) | IHC-P | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-501LC | Anti-Human CLDN4 Recombinant Antibody (KM3900) | WB, IP, FC | |
| TAB-504LC | Anti-Human CLDN4 Recombinant Antibody (KM3907) | Cyt, FC, WB | |
| TAB-506LC | Anti-Human CLDN4 Recombinant Antibody (TAB-506LC) | FC | |
| TAB-501LC-S(P) | Anti-Human CLDN4 Recombinant Antibody scFv Fragment (KM3900) | WB, IP | |
| TAB-504LC-S(P) | Anti-Human CLDN4 Recombinant Antibody scFv Fragment (KM3907) | WB, IP |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-503LC | Anti-Human CLDN4 Recombinant Antibody (Humanized KM3900) | Cyt, FC, WB | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-505LC | Anti-Human CLDN4 Recombinant Antibody (cKM3907) | Cyt, FC, WB | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC131 | Recombinant Anti-CLDN4 Vesicular Antibody, EV Displayed (VS-0425-YC131) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1487 | Anti-CLDN4 Immunohistochemistry Kit | IHC |
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