Recombinant Anti-DSG1 Vesicular Antibody, EV Displayed (VS-0425-YC194)
CAT#: VS-0425-YC194
The Recombinant Anti-DSG1 Vesicular Antibody, EV Displayed (VS-0425-YC194) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to DSG1-expressed cells or tissues. The DSG1 is a desmoglein protein, part of desmosomes, and is targeted by auto-antibodies in pemphigus foliaceus. Disruption of this gene is linked to skin diseases like palmoplantar keratoderma.
Gene Expression
Normal Tissue
Figure 1 Skin
Cells in basal layer
Staining:Medium
Intensity: Moderate
Quantity:>75%
Cells in corneal layer
Staining:High
Intensity: Strong
Quantity: 75%-25%
Cells in granular layer
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Cells in spinous layer
Staining:High
Intensity: Strong
Quantity:>75%
Langerhans cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22128/169913_B_8_1.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (hTCEpi)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134760-DSG1
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- DSG1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Desmoglein 1
- Biological Process
- Cell adhesion
- Introduction
- This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.
- Alternative Names
- CDHF4, DSG
- Gene ID
- 1828
- UniProt ID
- Q02413
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0319CL | Human Anti-DSG1 Recombinant Antibody (TAB-0319CL) | ELISA, IF, IP | Human IgG |
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| TAB-257MZ-S(P) | Human Anti-DSG1 Recombinant Antibody; scFv Fragment (TAB-257MZ-S(P)) | ELISA | Human scFv |
| TAB-257MZ-F(E) | Human Anti-DSG1 Recombinant Antibody; Fab Fragment (TAB-257MZ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1053 | Hi-Affi™ Rabbit Anti-DSG1 Recombinant Antibody (clone DS1053AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0206-CN-S(P) | Human Anti-DSG1 Recombinant Antibody (clone (D31)2/28); scFv Fragment | ELISA, IF, IB | Human scFv |
| FAMAB-0207-CN-S(P) | Human Anti-DSG1 Recombinant Antibody (clone (D31)12a/5); scFv Fragment | ELISA, IF, IB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0206-CN-F(E) | Human Anti-DSG1 Recombinant Antibody (clone (D31)2/28); Fab Fragment | ELISA, IF, IB | Human Fab |
| FAMAB-0207-CN-F(E) | Human Anti-DSG1 Recombinant Antibody (clone (D31)12a/5); Fab Fragment | ELISA, IF, IB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY698 | Anti-DSG1 Immunohistochemistry Kit | IHC | |
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