Human Anti-DSG1 Recombinant Antibody (clone (D31)12a/5); Fab Fragment (CAT#: FAMAB-0207-CN-F(E))
This is a human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. The clone (D31)12a/5 is a nonpathogenic antibody recognizes both Dsg1 and Dsg3, wherewa it demonstrates only 5–26% inhibition of binding to Dsg3 by EDTA.
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Normal Tissue
RNA Expression
Figure 1 Skin
(Cells in basal layer
Staining:Medium
Intensity: Moderate
Quantity:>75%
Cells in corneal layer
Staining:High
Intensity: Strong
Quantity: 75%-25%
Cells in granular layer
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Cells in spinous layer
Staining:High
Intensity: Strong
Quantity:>75%
Langerhans cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22128/169913_B_8_1.jpg
(Cells in basal layer
Staining:Medium
Intensity: Moderate
Quantity:>75%
Cells in corneal layer
Staining:High
Intensity: Strong
Quantity: 75%-25%
Cells in granular layer
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Cells in spinous layer
Staining:High
Intensity: Strong
Quantity:>75%
Langerhans cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22128/169913_B_8_1.jpg
Figure 2 RNA cell line category: Cell line enriched (hTCEpi)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134760-DSG1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134760-DSG1
Specifications
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human Fab
- Specificity
- Human DSG1
- Species Reactivity
- Human, Mouse
- Clone
- (D31)12a/5
- Applications
- ELISA, IF, IB
- Related Disease
- Pemphigus
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Desmoglein 1; Pemphigus Foliaceus Antigen; Desmosomal Glycoprotein 1; Cadherin Family Member 4; CDHF4; DG1; EPKHIA; EPKHE; PPKS1; SPPK1; DSG; DGI
- Gene ID
- 1828
- UniProt ID
- Q02413
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-786-sdAb | Recombinant Anti-Human DSG1 VHH Single Domain Antibody | IP, ChiP, IHC, ELISA | Llama VHH |
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