Human Anti-DSG1 Recombinant Antibody (clone (D31)2/28); scFv Fragment (CAT#: FAMAB-0206-CN-S(P))
This is a human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. The clone (D31)2/28 can interfere with adhesion mediated by both human Dsg3 and human Dsg1. While it recognized only mDsg1 and not mDsg3.
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Normal Tissue
RNA Expression
Figure 1 Skin
(Cells in basal layer
Staining:Medium
Intensity: Moderate
Quantity:>75%
Cells in corneal layer
Staining:High
Intensity: Strong
Quantity: 75%-25%
Cells in granular layer
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Cells in spinous layer
Staining:High
Intensity: Strong
Quantity:>75%
Langerhans cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22128/169913_B_8_1.jpg
(Cells in basal layer
Staining:Medium
Intensity: Moderate
Quantity:>75%
Cells in corneal layer
Staining:High
Intensity: Strong
Quantity: 75%-25%
Cells in granular layer
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Cells in spinous layer
Staining:High
Intensity: Strong
Quantity:>75%
Langerhans cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22128/169913_B_8_1.jpg
Figure 2 RNA cell line category: Cell line enriched (hTCEpi)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134760-DSG1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134760-DSG1
Specifications
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human scFv
- Specificity
- Human DSG1
- Species Reactivity
- Human, Mouse
- Clone
- (D31)2/28
- Applications
- ELISA, IF, IB
- Related Disease
- Pemphigus
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Desmoglein 1; Pemphigus Foliaceus Antigen; Desmosomal Glycoprotein 1; Cadherin Family Member 4; CDHF4; DG1; EPKHIA; EPKHE; PPKS1; SPPK1; DSG; DGI
- Gene ID
- 1828
- UniProt ID
- Q02413
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-786-sdAb | Recombinant Anti-Human DSG1 VHH Single Domain Antibody | IP, ChiP, IHC, ELISA | Llama VHH |
Customer Reviews and Q&As
Customer Review
Q&As
Easy-to-use Datasheet
The datasheet that came with the antibody has comprehensive and easy-to-use information that made my experimental setup go more smoothly.
Better Quality
This recombinant antibody is of outstanding quality. In every use, it has beyond our expectations.
Consistent and Durable
The antibody is stable for months and has a lengthy shelf life. The lot I've been using for different tests still functions just as well as it did at first.
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For Research Use Only. Not For Clinical Use.
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