Recombinant Anti-FLT4 Vesicular Antibody, EV Displayed (VS-0425-YC359) (CAT#: VS-0425-YC359)
The Recombinant Anti-FLT4 Vesicular Antibody, EV Displayed (VS-0425-YC359) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FLT4-expressed cells or tissues. The FLT4 is a receptor tyrosine kinase for VEGFs, which is critical for lymphatic endothelium maintenance, with mutations causing lymphedema.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression

Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46519/1909_G1_4_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46519/1909_G1_4_selected.jpg

Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/99/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/99/if_selected.jpg

Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67906/153589_A_9_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67906/153589_A_9_3.jpg

Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67906/153589_A_7_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67906/153589_A_7_5.jpg

Figure 5 RNA cell line category: Cell line enhanced (AN3-CA, BEWO, HEK93, HL-60, HUVEC TERT2, JURKAT, T-47d, TIME)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000037280-FLT4
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000037280-FLT4
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- FLT4
- Host Animal
- Mouse
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein G
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Fms related receptor tyrosine kinase 4
- Biological Process
- Angiogenesis
- Molecular Function
- Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Microtubules, Primary cilium, Cytokinetic bridge, Calyx, Connecting piece, Mid piece, Principal piece
- Introduction
- This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
- Alternative Names
- PCL, VEGFR-3, VEGFR3
- Gene ID
- 2324
- UniProt ID
- P35916
Downloads
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MOB-1490z | Mouse Anti-FLT4 Recombinant Antibody (clone 26D3) | WB, FC, IHC, IP | Mouse IgG2a, κ |
MOB-2181MZ | Recombinant Mouse Anti-Human FLT4 Antibody | ELISA, WB | Mouse antibody |
ZG-0353J | Mouse Anti-FLT4 Recombinant Antibody (ZG-0353J) | WB, ELISA | Mouse IgG |
VS3-CJ913 | Mouse Anti-FLT4 Recombinant Antibody (VS3-CJ913) | IHC | Mouse IgG |
VS7-HM959 | Mouse Anti-FLT4 Recombinant Antibody (clone CBL290HM) | WB, ELISA | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
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