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Anti-FLT4 Recombinant Antibody Products

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Anti-FLT4 Products

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For Research Use Only. Not For Clinical Use.


At Creative Biolabs, we are proud to offer a superior range of anti-FLT4 recombinant antibody products, meticulously engineered to meet the stringent demands of global research and therapeutic development. Our cutting-edge antibodies provide unparalleled specificity and performance, empowering scientists worldwide to accelerate their discoveries in critical biological pathways and disease mechanisms.

FLT4: A Promising Target for Cancer Therapy

Fms-like tyrosine kinase 4 (FLT4), also known as Vascular Endothelial Growth Factor Receptor 3 (VEGFR-3), is a receptor tyrosine kinase primarily involved in lymphangiogenesis and vascular development. Its critical function in lymphatic vessel formation positions it as a key player in both normal physiology and various pathological conditions. Recent research consistently highlights FLT4's significant role in disease progression, particularly its contribution to cancer progression and metastasis by promoting tumor angiogenesis and facilitating lymphatic spread. Studies, such as those focusing on novel peptides targeting FLT4, increasingly demonstrate its therapeutic potential, especially in challenging malignancies like acute myeloid leukemia (AML). This underscores its importance as a compelling target for developing innovative treatments and diagnostic tools.

Alternative Names

Fms-related tyrosine kinase 4; FLT41; LMPH1A; PCL; VEGFR3; FLT-4; VEGFR-3; fms related tyrosine kinase 4; LMPHM1; fms related receptor tyrosine kinase 4; CHTD7.

Background

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.

Protein class

Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, RAS pathway related proteins

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Group enriched (Hepatic stellate cells, Extravillous trophoblasts, Adipocytes, Endothelial cells)

Immune cell specificity

Immune cell enriched (MAIT T-cell)

Cell line specificity

Cell line enhanced (AN3-CA, BEWO, HEK93, HL-60, HUVEC TERT2, JURKAT, T-47d, TIME)

Interaction

Interacts with VEGFC and VEGFD. Monomer in the absence of bound VEGFC or VEGFD. Homodimer in the presence of bound VEGFC or VEGFD. Can also form a heterodimer with KDR. Interacts with PTPN14; the interaction is enhanced by stimulation with VEGFC. Interacts with CRK, GRB2, PTK2/FAK1, SHC1, PIK3R1 and PTPN11/SHP-2. Identified in a complex with SRC and ITGB1.

Molecular function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

More Types Infomation

Anti-FLT4 rAb Products

Our anti-FLT4 recombinant antibody products are meticulously designed with superior specificity and affinity, ensuring reliable and precise detection and modulation of FLT4. This high degree of specificity is crucial for minimizing off-target binding and ensuring accurate experimental results in diverse applications. Produced using advanced recombinant technology, these antibodies offer exceptional batch-to-batch consistency, which is vital for research reproducibility across multiple experiments and long-term studies, and significantly reduced immunogenicity, a key advantage for potential preclinical development and therapeutic applications. Their high purity and robust performance provide researchers with a truly dependable and versatile tool for their most critical experiments, from fundamental target validation to complex functional studies and drug screening.

Cat. No. Product Name Target Species Host Species Applications
TAB-292CL Human Anti-FLT4 Recombinant Antibody (TAB-292CL) Human Human IgG1 ELISA
ZG-0353J Mouse Anti-FLT4 Recombinant Antibody (ZG-0353J) Human Mouse IgG WB, ELISA
VS3-QX433 Mouse Anti-FLT4 Recombinant Antibody (clone 818CT12.1.1) Human Mouse IgG2a WB, IHC, FC
VS3-XY715 Mouse Anti-FLT4 Recombinant Antibody (clone 4H4) Mouse IgG1 ELISA, WB
MOB-2181MZ Recombinant Mouse Anti-Human FLT4 Antibody Human Mouse antibody ELISA, WB

Table 1. Featured anti-FLT4 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs implements a rigorous quality control process for all anti-FLT4 recombinant antibodies. Each product undergoes comprehensive validation, including ELISA, Western Blot, flow cytometry, and immunohistochemistry, to guarantee optimal performance, specificity, and sensitivity. This meticulous approach ensures that our antibodies consistently meet the highest industry standards, providing researchers with confidence in their experimental results.

SDS-PAGE analysis. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-FLT4 antibody
(Cat# TAB-292CL, Creative Biolabs).

WB analysis. (Creative Biolabs Original)Fig.2 WB analysis of anti-FLT4 antibody
(Cat# ZG-0353J, Creative Biolabs).

Customer Reviews

Excellent
Da***s
Mouse Anti-FLT4 Recombinant Antibody (clone 818CT12.1.1) (VS3-QX433)
Creative Biolabs' anti-FLT4 recombinant antibody exceeded our expectations. Its excellent specificity and minimal background noise greatly enhanced our IHC staining findings, saving us considerable time and resources. A wonderfully dependable product!
17/Nov/2024
Excellent
Ki***m
Human Anti-FLT4 Recombinant Antibody (TAB-292CL) (TAB-292CL)
In our functional testing, Creative Biolabs' anti-FLT4 antibody has consistently performed well. The uniformity across batches is exceptional, which is critical for our long-term research efforts. Highest recommendation for demanding applications.
21/Dec/2024
Excellent
Da***d
Recombinant Rabbit Anti-FLT4 Detection Antibody (clone R12-4S-1) (VS3-WK1957)
Using Creative Biolabs' anti-FLT4 recombinant antibody has streamlined our flow cytometry experiments. The clear separation and strong signal allowed us to accurately identify FLT4-expressing cells, accelerating our understanding of lymphatic vessel biology. Excellent product quality!
29/Jan/2025

rAb Production

Our anti-FLT4 recombinant antibodies are produced in state-of-the-art facilities utilizing proprietary expression systems, ensuring high yield and purity. We employ stringent purification protocols to minimize contaminants, delivering a product that is highly active and suitable for diverse research and therapeutic applications, from basic research to drug discovery.

Featured Anti-FLT4 Recombinant Antibody Production PlatformsMilligram-scale. (Creative Biolabs Original)
Fig.3 Milligram-scale anti-FLT4 recombinant antibody production.

Gram-scale. (Creative Biolabs Original)Fig.4 Gram-scale anti-FLT4 recombinant antibody production.

rAb Modalities

Creative Biolabs offers anti-FLT4 recombinant antibodies in multiple modalities, providing flexibility for various experimental designs and applications.

FLT4 antibody production and modalities. (Creative Biolabs Original)Fig.5 Full-length anti-FLT4 recombinant antibody production and modalities.

FLT4-Targeted Drug Information

Organization Research phase Product Category Condition
Akeso Biopharma (Originator) Phase III Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer, gastroesophageal junction (adenocarcinoma)
Cancer, gastrointestinal
Cancer, solid tumor
AffaMed Therapeutics
Allgenesis Biotherapeutics (Originator)
Phase II Fc Fusion Proteins
Polypeptides, from 41 AA
Diabetic macular edema
Fibrosis
Inflammatory disorders
Neovascularization, retinal
Occlusion, retinal vein
Wet macular degeneration (exudative)
Shanghai Henlius Biotech (Originator) Phase I Cancer Immunotherapy
Follow-on Products
Human Monoclonal Antibodies
Cancer
Cancer, colorectal, metastatic
Cancer, gastroesophageal junction (adenocarcinoma)
Cancer, lung (non-small cell) (NSCLC)
Cancer, stomach
LynkCell (Originator) Phase I Humanized Monoclonal Antibodies Cancer, cervix
Cancer, colorectal
Cancer, ovary
Cancer, solid tumor
Cancer, stomach
MabSpace Biosciences (Transcenta)
Transcenta (Originator)
Phase I Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer, solid tumor
Henlix Biotech (Originator) Phase I Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer, solid tumor
Beijing Dongfang Biotech (Originator) Clinical Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer, lung (non-small cell) (NSCLC)
University of Pennsylvania (Originator) Preclinical CRISPR/Cas9 System Nucleases
Lipid Nanoparticles
Single Guide RNA (sgRNA)
Single-stranded oligoribonucleotide (RNA)
Cancer, lung
Universite de Lausanne (Originator) Preclinical Cancer Immunotherapy
Chimeric Antigen Receptor-Modified T Cells (CAR T Cells) (Second-Generation CAR)
Melanoma
Zhengzhou University (Originator) Preclinical Double-stranded oligoribonucleotide (RNA)
Micelles
Nanoparticles
Small Interfering RNA (SiRNAs)
Pre-eclampsia
Food and Drug Administration (Originator) Preclinical Bispecific Antibody Fusions
Cancer Immunotherapy
Fusion Proteins
Polypeptides, from 41 AA
Single-Chain V-Domain Antibody Fragment (scFv)
Triple negative breast cancer
University of Mississippi Medical Center (Originator) Preclinical Carrier-Mediated Drug Delivery
Fusion Proteins
Polypeptides, from 41 AA
Vascular Endothelial Growth Factors (VEGF)
Hypertension, pregnancy-induced

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Table 2. Public drug targeting FLT4.

Creative Biolabs is committed to improving scientific research with our excellent anti-FLT4 recombinant antibody solutions. We encourage you to browse our wide portfolio and learn how our experience may help you achieve your next breakthrough. Please contact us if you want precise details, specialized solutions, or want to discuss your specific project requirements.

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