Recombinant Anti-GPNMB Vesicular Antibody, EV Displayed (VS-0425-YC81)
CAT#: VS-0425-YC81
The Recombinant Anti-GPNMB Vesicular Antibody, EV Displayed (VS-0425-YC81) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GPNMB-expressed cells or tissues. The GPNMB is a transmembrane protein involved in cell growth regulation, associated with conditions like Melanoma.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (ASC diff)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136235-GPNMB
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GPNMB
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Glycoprotein nmb
- Introduction
- The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. GPNMB (Glycoprotein Nmb) is a Protein Coding gene. Diseases associated with GPNMB include Melanoma and Glioblastoma Multiforme. Among its related pathways are Signaling by GPCR and Signaling by PTK6. Gene Ontology (GO) annotations related to this gene include heparin binding and integrin binding. An important paralog of this gene is PMEL. Could be a melanogenic enzyme.
- Alternative Names
- HGFIN, NMB
- Gene ID
- 10457
- UniProt ID
- Q14956
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Datasheet
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1138-VHH | Recombinant Anti-Human GPNMB VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
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| TAB-751 | Human Anti-GPNMB Recombinant Antibody (clone Glembatumumab) | WB, IF, IP, Neut, FuncS, ELISA, FC | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4197 | Rabbit Anti-GPNMB Recombinant Antibody (clone SI275DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0005-LS-F(E) | Rabbit Anti-GPNMB Recombinant Antibody; Fab Fragment (HPAB-0005-LS-F(E)) | FC | Rabbit Fab |
| HPAB-0006-LS-F(E) | Human Anti-GPNMB Recombinant Antibody Fab Fragment (HPAB-0006-LS-F(E)) | ELISA | Human Fab |
| HPAB-1535-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2); Fab Fragment | Inhib, ELISA | Human Fab |
| HPAB-1536-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2); Fab Fragment | Inhib, ELISA | Human Fab |
| HPAB-1537-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.7.1); Fab Fragment | Inhib, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0005-LS-S(P) | Rabbit Anti-GPNMB Recombinant Antibody; scFv Fragment (HPAB-0005-LS-S(P)) | FC | Rabbit scFv |
| HPAB-0006-LS-S(P) | Human Anti-GPNMB Recombinant Antibody scFv Fragment (HPAB-0006-LS-S(P)) | ELISA | Human scFv |
| HPAB-1535-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2); scFv Fragment | Inhib, ELISA | Human scFv |
| HPAB-1536-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2); scFv Fragment | Inhib, ELISA | Human scFv |
| HPAB-1537-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.7.1); scFv Fragment | Inhib, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-020CQ | Mouse Anti-GPNMB Recombinant Antibody (clone YC095) | WB, IHC, FC | Mouse IgG2b |
| MOB-122CQ | Rat Anti-GPNMB Recombinant Antibody (clone YC096) | ELISA, WB | Rat IgG2b |
| MOB-123CQ | Rat Anti-GPNMB Recombinant Antibody (clone YC097) | FC | Rat IgG2a |
| HPAB-1535-FY | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2) | Inhib, ELISA | Human IgG |
| HPAB-1536-FY | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2) | Inhib, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-751 | Afuco™ Anti-GPNMB ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-751) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY944 | Anti-GPNMB Immunohistochemistry Kit | IHC | |
| VS-0525-XY2890 | Anti-Human GPNMB Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY114 | Human Anti-GPNMB scFv-Fc Chimera (VS-0425-FY114) | ELISA, FC | Human IgG2, scFv-Fc |
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