Human Anti-GPNMB scFv-Fc Chimera (VS-0425-FY114)
CAT#: VS-0425-FY114
This fusion protein targets GPNMB (Glycoprotein non-metastatic melanoma B), a protein involved in cell adhesion and migration. By inhibiting GPNMB, it can modulate cellular behavior and has potential applications in cancer and neurodegenerative diseases.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (ASC diff)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136235-GPNMB
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Specifications
- Immunogen
- Human GPNMB extracellular domain.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human GPNMB
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Glycoprotein Nmb; Hematopoietic Growth Factor Inducible Neurokinin-1; Glycoprotein Nonmetastatic Melanoma Protein B; Glycoprotein (Transmembrane) Nmb; Transmembrane Glycoprotein HGFIN; Glycoprotein Nmb-Like Protein; Glycoprotein NMB
- Gene ID
- 10457
- UniProt ID
- Q14956
- Long Name
- Glycoprotein Nmb
- Sequence Similarities
- Belongs to the PMEL/NMB family.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein; Melanosome membrane; Single-pass type I membrane protein; Early endosome membrane
- Post Translation Modifications
- Glycosylation at Asn93, Asn134, Asn146, Asn200, Asn249, Asn275, Asn296, Asn300, Asn306, Asn312, Asn459, and Asn467
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect GPNMB_HUMAN (1847)
Glycosylation from GlyGen 14 sites, 209 N-linked glycans (4 sites), 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_005249635.1; XP_016867167.1; XP_047275732.1; XP_054213063.1; XP_054213064.1
- Function
- Could be a melanogenic enzyme.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "GPNMB"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1138-VHH | Recombinant Anti-Human GPNMB VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-751 | Human Anti-GPNMB Recombinant Antibody (clone Glembatumumab) | WB, IF, IP, Neut, FuncS, ELISA, FC | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4197 | Rabbit Anti-GPNMB Recombinant Antibody (clone SI275DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0005-LS | Rabbit Anti-GPNMB Recombinant Antibody (HPAB-0005-LS) | WB, FC | Rabbit IgG |
| HPAB-0006-LS | Human Anti-GPNMB Recombinant Antibody (HPAB-0006-LS) | ELISA, FC | Human IgG2 |
| HPAB-1535-FY | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2) | Inhib, ELISA | Human IgG |
| HPAB-1536-FY | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2) | Inhib, ELISA | Human IgG |
| HPAB-1537-FY | Human Anti-GPNMB Recombinant Antibody (clone 1.7.1) | Inhib, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0005-LS-F(E) | Rabbit Anti-GPNMB Recombinant Antibody; Fab Fragment (HPAB-0005-LS-F(E)) | FC | Rabbit Fab |
| HPAB-0006-LS-F(E) | Human Anti-GPNMB Recombinant Antibody Fab Fragment (HPAB-0006-LS-F(E)) | ELISA | Human Fab |
| HPAB-1535-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2); Fab Fragment | Inhib, ELISA | Human Fab |
| HPAB-1536-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2); Fab Fragment | Inhib, ELISA | Human Fab |
| HPAB-1537-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.7.1); Fab Fragment | Inhib, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0005-LS-S(P) | Rabbit Anti-GPNMB Recombinant Antibody; scFv Fragment (HPAB-0005-LS-S(P)) | FC | Rabbit scFv |
| HPAB-0006-LS-S(P) | Human Anti-GPNMB Recombinant Antibody scFv Fragment (HPAB-0006-LS-S(P)) | ELISA | Human scFv |
| HPAB-1535-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2); scFv Fragment | Inhib, ELISA | Human scFv |
| HPAB-1536-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2); scFv Fragment | Inhib, ELISA | Human scFv |
| HPAB-1537-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.7.1); scFv Fragment | Inhib, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-751 | Afuco™ Anti-GPNMB ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-751) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY944 | Anti-GPNMB Immunohistochemistry Kit | IHC | |
| VS-0525-XY2890 | Anti-Human GPNMB Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC81 | Recombinant Anti-GPNMB Vesicular Antibody, EV Displayed (VS-0425-YC81) | ELISA, FC, Neut, Cell-uptake |
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