Human Anti-GPNMB scFv-Fc Chimera (VS-0425-FY114) (CAT#: VS-0425-FY114)
This fusion protein targets GPNMB (Glycoprotein non-metastatic melanoma B), a protein involved in cell adhesion and migration. By inhibiting GPNMB, it can modulate cellular behavior and has potential applications in cancer and neurodegenerative diseases.
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RNA Expression
Figure 1 RNA cell line category: Cell line enriched (ASC diff)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136235-GPNMB
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136235-GPNMB
Specifications
- Immunogen
- Human GPNMB extracellular domain.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human GPNMB
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Glycoprotein Nmb; Hematopoietic Growth Factor Inducible Neurokinin-1; Glycoprotein Nonmetastatic Melanoma Protein B; Glycoprotein (Transmembrane) Nmb; Transmembrane Glycoprotein HGFIN; Glycoprotein Nmb-Like Protein; Glycoprotein NMB
- Gene ID
- 10457
- UniProt ID
- Q14956
- Long Name
- Glycoprotein Nmb
- Sequence Similarities
- Belongs to the PMEL/NMB family.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein; Melanosome membrane; Single-pass type I membrane protein; Early endosome membrane
- Post Translation Modifications
- Glycosylation at Asn93, Asn134, Asn146, Asn200, Asn249, Asn275, Asn296, Asn300, Asn306, Asn312, Asn459, and Asn467
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect GPNMB_HUMAN (1847)
Glycosylation from GlyGen 14 sites, 209 N-linked glycans (4 sites), 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_005249635.1; XP_016867167.1; XP_047275732.1; XP_054213063.1; XP_054213064.1
- Function
- Could be a melanogenic enzyme.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1138-VHH | Recombinant Anti-Human GPNMB VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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