Recombinant Anti-GUCY2C Vesicular Antibody, EV Displayed (VS-0425-YC498)
CAT#: VS-0425-YC498
The Recombinant Anti-GUCY2C Vesicular Antibody, EV Displayed (VS-0425-YC498) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GUCY2C-expressed cells or tissues. GUCY2C is a receptor for guanylin peptides and E. coli enterotoxin, associated with familial diarrhea. GUCY2C activates the cystic fibrosis transmembrane regulator.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73759/1520_C2_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_B_9_5.jpg
Normal Tissue
Figure 4 Oral mucosa
Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_8_1.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_8_3.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, CACO-2, CAPAN-2, SiHa)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070019-GUCY2C
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GUCY2C
- Host Animal
- Rabbit
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Guanylate cyclase 2C
- Biological Process
- cGMP biosynthesis
- Molecular Function
- Lyase, Receptor
- Cellular Localization
- Vesicles
- Introduction
- This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). [provided by RefSeq, Nov 2016]
- Alternative Names
- GUC2C, STAR
- Gene ID
- 2984
- UniProt ID
- P25092
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2397z-F(E) | Recombinant Anti-Human GUCY2C Antibody Fab Fragment | Neut, IF, FuncS | Fab |
| HPAB-AP097-YC-F(E) | Rabbit Anti-GUCY2C Recombinant Antibody; Fab Fragment (HPAB-AP097-YC-F(E)) | ELISA, IHC | Rabbit Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2397z-S(P) | Recombinant Anti-Human GUCY2C Antibody scFv Fragment | IF, FC, Biosensors, FuncS | scFv |
| HPAB-AP097-YC-S(P) | Rabbit Anti-GUCY2C Recombinant Antibody; scFv Fragment (HPAB-AP097-YC-S(P)) | ELISA, IHC | Rabbit scFv |
| HPAB-AP098-YC-S(P) | Rabbit Anti-GUCY2C Recombinant Antibody; scFv Fragment (HPAB-AP098-YC-S(P)) | ELISA, IHC | Rabbit scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-061CQ | Mouse Anti-GUCY2C Recombinant Antibody (TAB-061CQ) | ELISA, FC, IF | Mouse IgG1, κ |
| TAB-062CQ | Human Anti-GUCY2C Recombinant Antibody (TAB-062CQ) | ELISA, FC, WB | Chimeric (mouse/human) IgG |
| TAB-061CQ-S(P) | Mouse Anti-GUCY2C Recombinant Antibody; scFv Fragment (TAB-061CQ-S(P)) | ELISA, FC, WB | Mouse scFv |
| TAB-062CQ-S(P) | Mouse Anti-GUCY2C Recombinant Antibody; scFv Fragment (TAB-062CQ-S(P)) | ELISA, FC, WB | Mouse scFv |
| TAB-061CQ-F(E) | Mouse Anti-GUCY2C Recombinant Antibody; Fab Fragment (TAB-061CQ-F(E)) | ELISA, FC, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0245MZ | Chicken Anti-GUCY2C Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY115 | Human Anti-GUCY2C scFv-Fc Chimera (VS-0425-FY115) | WB, ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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