Human Anti-GUCY2C scFv-Fc Chimera (VS-0425-FY115)
CAT#: VS-0425-FY115
This scFv-Fc fusion protein targets GUCY2C (Guanylate cyclase 2C), a receptor involved in intestinal homeostasis and signaling. By modulating GUCY2C activity, it can influence gastrointestinal function and has potential applications in treating gastrointestinal disorders.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73759/1520_C2_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_B_9_5.jpg
Normal Tissue
Figure 4 Oral mucosa
Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_8_1.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_8_3.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, CACO-2, CAPAN-2, SiHa)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070019-GUCY2C
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Specifications
- Immunogen
- Using the extracellular domain of GCC as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GUCY2C
- Species Reactivity
- Human, Mouse
- Applications
- Western Blot, ELISA, Flow Cytometry
- Related Disease
- Diarrhea 6 and Meconium Ileus
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Guanylate Cyclase 2C; STA Receptor; Intestinal Guanylate Cyclase; Guanylyl Cyclase C; EC 4.6.1.2; GUC2C; STAR; GC-C; Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)
- Gene ID
- 2984
- UniProt ID
- P25092
- Long Name
- Guanylate Cyclase 2C
- Sequence Similarities
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein; Endoplasmic reticulum membrane
- Post Translation Modifications
- Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GUCY2C activation.
Glycosylation at Asn32, Asn75, Asn79, Asn195, Asn284, Asn307, Asn345, and Asn402
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 8 sites, 1 N-linked glycan (1 site)
- Protein Refseq
- XP_011518933.1; XP_054227852.1; NP_004954.2
- Function
- Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP.
Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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| MOB-2397z-F(E) | Recombinant Anti-Human GUCY2C Antibody Fab Fragment | Neut, IF, FuncS | Fab |
| HPAB-AP097-YC-F(E) | Rabbit Anti-GUCY2C Recombinant Antibody; Fab Fragment (HPAB-AP097-YC-F(E)) | ELISA, IHC | Rabbit Fab |
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| CAT | Product Name | Application | Type |
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| MOB-2397z-S(P) | Recombinant Anti-Human GUCY2C Antibody scFv Fragment | IF, FC, Biosensors, FuncS | scFv |
| HPAB-AP097-YC-S(P) | Rabbit Anti-GUCY2C Recombinant Antibody; scFv Fragment (HPAB-AP097-YC-S(P)) | ELISA, IHC | Rabbit scFv |
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| CAT | Product Name | Application | Type |
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| TAB-061CQ | Mouse Anti-GUCY2C Recombinant Antibody (TAB-061CQ) | ELISA, FC, IF | Mouse IgG1, κ |
| TAB-062CQ | Human Anti-GUCY2C Recombinant Antibody (TAB-062CQ) | ELISA, FC, WB | Chimeric (mouse/human) IgG |
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| TAB-061CQ-F(E) | Mouse Anti-GUCY2C Recombinant Antibody; Fab Fragment (TAB-061CQ-F(E)) | ELISA, FC, WB | Mouse Fab |
| TAB-062CQ-F(E) | Human Anti-GUCY2C Recombinant Antibody; Fab Fragment (TAB-062CQ-F(E)) | ELISA, FC, WB | Chimeric (mouse/human) Fab |
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| BRD-0245MZ | Chicken Anti-GUCY2C Polyclonal IgY | WB | Chicken antibody |
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