Recombinant Anti-HAVCR2 Vesicular Antibody, EV Displayed (VS-0425-YC542)
CAT#: VS-0425-YC542
The Recombinant Anti-HAVCR2 Vesicular Antibody, EV Displayed (VS-0425-YC542) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to HAVCR2-expressed cells or tissues. HAVCR2 is a protein part of the immunoglobulin superfamily, involved in regulating T helper lymphocyte functions. It plays a role in macrophage activation and promoting immunological tolerance.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_9_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_9_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_5_6.jpg
Normal Tissue
Figure 5 High expression in lymph node.
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_8_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, Daudi, HDLM-2, HMC-1, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135077-HAVCR2
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- HAVCR2
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Hepatitis A virus cellular receptor 2
- Biological Process
- Adaptive immunity, Immunity, Inflammatory response, Innate immunity
- Introduction
- The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
- Alternative Names
- CD366, FLJ14428, Tim-3, TIM3, TIMD3
- Gene ID
- 84868
- UniProt ID
- Q8TDQ0
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Datasheet
MSDS
COA
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| HPAB-1047LY-S(P) | Human Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-1047LY-S(P)) | ELISA | Human scfv |
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| CAT | Product Name | Application | Type |
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| HPAB-1047LY | Human Anti-HAVCR2 Recombinant Antibody (HPAB-1047LY) | ELISA | Human IgG |
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| HPAB-1049LY | Human Anti-HAVCR2 Recombinant Antibody (HPAB-1049LY) | ELISA | Human IgG |
| HPAB-1050LY | Human Anti-HAVCR2 Recombinant Antibody (HPAB-1050LY) | ELISA | Human IgG |
| HPAB-1051LY | Human Anti-HAVCR2 Recombinant Antibody (HPAB-1051LY) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1047LY-F(E) | Human Anti-HAVCR2 Recombinant Antibody; Fab Fragment (HPAB-1047LY-F(E)) | ELISA | Human Fab |
| HPAB-1048LY-F(E) | Human Anti-HAVCR2 Recombinant Antibody; Fab Fragment (HPAB-1048LY-F(E)) | ELISA | Human Fab |
| HPAB-1049LY-F(E) | Human Anti-HAVCR2 Recombinant Antibody; Fab Fragment (HPAB-1049LY-F(E)) | ELISA | Human Fab |
| HPAB-1050LY-F(E) | Human Anti-HAVCR2 Recombinant Antibody; Fab Fragment (HPAB-1050LY-F(E)) | ELISA | Human Fab |
| HPAB-1051LY-F(E) | Human Anti-HAVCR2 Recombinant Antibody; Fab Fragment (HPAB-1051LY-F(E)) | ELISA | Human Fab |
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| CAT | Product Name | Application | Type |
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