Recombinant Anti-IL10RA Vesicular Antibody, EV Displayed (VS-0425-YC589) (CAT#: VS-0425-YC589)

• Application
• Block, ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• IL10RA

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Chimpanzee, Cynomolgus

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Interleukin 10 receptor subunit alpha

• Molecular Function
• Receptor

• Cellular Localization
• Plasma membrane, Cytosol, Primary cilium

• Introduction
• The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

• Alternative Names
• CD210, CD210a, CDW210A, HIL-10R, IL10R

• Gene ID
• 3587

• UniProt ID
• Q13651

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