Recombinant Anti-IL10RA Vesicular Antibody, EV Displayed (VS-0425-YC589)

CAT#: VS-0425-YC589

The Recombinant Anti-IL10RA Vesicular Antibody, EV Displayed (VS-0425-YC589) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL10RA-expressed cells or tissues. IL10RA is a receptor for interleukin 10, inhibiting proinflammatory cytokine synthesis. It promotes myeloid cell survival through the PI 3-kinase/AKT pathway, with activation leading to kinase phosphorylation. Two transcript variants exist for this gene.

Gene Expression
Figure 1 IF staining of human cell line HDLM-2 Figure 2 IF staining of human cell line K-562 Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, RPMI-8226)

Recombinant Antibody

  • Application
  • Block, ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • IL10RA
  • Host Animal
  • Human
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human, Chimpanzee, Cynomolgus
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • z domain
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Binding Affinity
  • Kd = 0.85 µg/mL
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Interleukin 10 receptor subunit alpha
  • Molecular Function
  • Receptor
  • Cellular Localization
  • Plasma membrane, Cytosol, Primary cilium
  • Introduction
  • The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
  • Alternative Names
  • CD210, CD210a, CDW210A, HIL-10R, IL10R
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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