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IL10RA
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- Recombinant Anti-human IL10RA Antibody (MOB-550)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, IHC, FuncS
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- Species Reactivity: Human, African green monkey, Baboon, Cynomolgus, Rhesus
- Type: Rat IgG2a
- Application: FC
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- Mouse Anti-IL10RA Antibody, mRNA (AGTO-G039E-mRNA)
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- Species Reactivity: Human
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- Human Anti-IL10RA Antibody, mRNA (TAB-391CL-mRNA)
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- Species Reactivity: Human
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- Human Anti-IL10RA Recombinant Antibody (HPAB-0277-CN) (HPAB-0277-CN)
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- Species Reactivity: Human, Chimpanzee, Cynomolgus
- Type: Human IgG2
- Application: ELISA, FC, Block, Neut
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- Human Anti-IL10RA Recombinant Antibody (HPAB-0278-CN) (HPAB-0278-CN)
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- Species Reactivity: Human, Chimpanzee, Cynomolgus
- Type: Human IgG4
- Application: ELISA, FC, Block, Neut
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- Mouse Anti-IL10RA Recombinant Antibody (clone CBL463) (NEUT-1134CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut
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- Mouse Anti-IL10RA Recombinant Antibody (clone 7Q35) (NEUT-1135CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2
- Application: Neut
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- Mouse Anti-IL10RA Recombinant Antibody (clone 37607.11) (NEUT-1136CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut
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- Rat Anti-Il10ra Recombinant Antibody (NEUT-1137CQ) (NEUT-1137CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: Block, FC, IHC-Fr
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- Rat Anti-Il10ra Recombinant Antibody (clone 1B1.3A) (NEUT-1138CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG1
- Application: Block, FC, WB
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- Human Anti-IL10RA Recombinant Antibody (HPAB-0276-CN) (HPAB-0276-CN)
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- Species Reactivity: Human, Chimpanzee, Cynomolgus
- Type: Human IgG1
- Application: ELISA, FC, Block, Neut
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- Rat Anti-IL10RA Recombinant Antibody (clone 3F9) (NEUT-1132CQ)
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- Species Reactivity: Human, Cynomolgus, Rhesus
- Type: Rat IgG2a, κ
- Application: FC, IP, Block
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- Mouse Anti-IL10RA Recombinant Antibody (clone CBL076) (NEUT-1133CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2
- Application: WB, Neut
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- IL-10-PE immunotoxin (AGTO-G039E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Anti-Human IL10RA Recombinant Antibody (TAB-391CL)
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- Species Reactivity: Human
- Type: Antibody
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- Human Anti-IL10RA Recombinant Antibody; scFv Fragment (HPAB-0276-CN-S(P)) (HPAB-0276-CN-S(P))
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- Species Reactivity: Human, Chimpanzee, Cynomolgus
- Type: Human scFv
- Application: ELISA, FC, Block, Neut
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- Human Anti-IL10RA Recombinant Antibody; scFv Fragment (HPAB-0277-CN-S(P)) (HPAB-0277-CN-S(P))
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- Species Reactivity: Human, Chimpanzee, Cynomolgus
- Type: Human scFv
- Application: ELISA, FC, Block, Neut
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- Human Anti-IL10RA Recombinant Antibody; scFv Fragment (HPAB-0278-CN-S(P)) (HPAB-0278-CN-S(P))
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- Species Reactivity: Human, Chimpanzee, Cynomolgus
- Type: Human scFv
- Application: ELISA, FC, Block, Neut
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- Human Anti-IL10RA Recombinant Antibody; Fab Fragment (HPAB-0276-CN-F(E)) (HPAB-0276-CN-F(E))
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- Species Reactivity: Human, Chimpanzee, Cynomolgus
- Type: Human Fab
- Application: ELISA, FC, Block, Neut
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- Recombinant Anti-human IL10RA Antibody Fab Fragment (MOB-550-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, RIA, FuncS
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- Recombinant Anti-human IL10RA Antibody scFv Fragment (MOB-550-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IF, FC, Biosensors, FuncS
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- Human Anti-IL10RA Recombinant Antibody; Fab Fragment (HPAB-0277-CN-F(E)) (HPAB-0277-CN-F(E))
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- Species Reactivity: Human, Chimpanzee, Cynomolgus
- Type: Human Fab
- Application: ELISA, FC, Block, Neut
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- Human Anti-IL10RA Recombinant Antibody; Fab Fragment (HPAB-0278-CN-F(E)) (HPAB-0278-CN-F(E))
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- Species Reactivity: Human, Chimpanzee, Cynomolgus
- Type: Human Fab
- Application: ELISA, FC, Block, Neut
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- Recombinant Human Anti-human IL10RA Antibody Fab Fragment (MHH-550-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, IF, FuncS
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- Recombinant Human Anti-human IL10RA Antibody scFv Fragment (MHH-550-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, IF, FuncS
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- Human Anti-IL10RA (clone 136C5) scFv-Fc Chimera (VS-0325-FY25)
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- Species Reactivity: Human
- Type: Human IgG1, scFv-Fc
- Application: ELISA, FC, Block, Neut
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- Species Reactivity: Human, Chimpanzee, Cynomolgus
- Target: IL10RA
- Host Animal: Human
- Application: Block, ELISA, FC, Cell-uptake
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- Anti-IL10RA Immunohistochemistry Kit (VS-0525-XY3478)
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- Species Reactivity: Human
- Target: IL10RA
- Application: IHC
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- Anti-Mouse IL10RA Immunohistochemistry Kit (VS-0525-XY3479)
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- Species Reactivity: Mouse
- Target: IL10RA
- Application: IHC
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- CytoStream™ Rat Anti-IL10RA Recombinant Antibody (clone 1B1.3a) (VS-0225-XY126)
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- Species Reactivity: Mouse
- Type: Rat IgG1, kappa
- Application: FC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Protein class
CD markers, Disease related genes, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Kupffer cells, monocytes, Langerhans cells, Plasma cells, Macrophages, NK-cells, T-cells, Extravillous trophoblasts, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, HDLM-2, Karpas-707, RPMI-8226)
Interaction
Interacts with IL10 (PubMed:16982608, 15837194). Interacts with IL10RB (PubMed:16982608). Interacts (via its cytoplasmic domain) with JAK1 (via N-terminus) (PubMed:12133952). Interacts with BTRC; this interaction leads to IL10RA ubiquitination and subsequent degradation (PubMed:22087322). Interacts with STAT3 (By similarity). (Microbial infection) Interacts with human cytomegalovirus protein IL10. (Microbial infection) Interacts with Epstein-Barr virus protein IL10.
Molecular function
Receptor
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