Recombinant Anti-IL23R Vesicular Antibody, EV Displayed (VS-0425-YC108)

Name: Recombinant Anti-IL23R Vesicular Antibody, EV Displayed (VS-0425-YC108)
SKU: VS-0425-YC108
Rating: 5 (1 reviews)

CAT#: VS-0425-YC108

The Recombinant Anti-IL23R Vesicular Antibody, EV Displayed (VS-0425-YC108) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL23R-expressed cells or tissues. The IL23R is a receptor subunit for IL23A signaling, affecting immune response regulation.

Gene Expression

Normal Tissue Figure 1 IHC staining of human bronchus

Immunohistochemical staining of human bronchus shows distinct positivity in a subset of leukocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56427/ihc_selected.jpg

Normal Tissue Figure 2 Cerebral cortex

Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56427/131561_B_7_5.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56427/131561_A_9_3.jpg

Normal Tissue Figure 4 Kidney

Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56427/131561_A_8_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56427/131561_A_6_6.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (HL-60, HMC-1, K-562, U-2197)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000162594-IL23R

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Recombinant Antibody

Application
ELISA, FC, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
IL23R

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Interleukin 23 receptor

Biological Process
Immunity, Inflammatory response, Innate immunity

Molecular Function
Receptor

Introduction
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Alternative Names
IL-23R

Gene ID
149233

UniProt ID
Q5VWK5

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Downloadable Resources

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Datasheet

Datasheet - VS-0425-YC108.pdf

MSDS

MSDS - VS-0425-YC108.pdf

COA

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