Recombinant Anti-IL31RA Vesicular Antibody, EV Displayed (VS-0425-YC523)
CAT#: VS-0425-YC523
The Recombinant Anti-IL31RA Vesicular Antibody, EV Displayed (VS-0425-YC523) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL31RA-expressed cells or tissues. IL31RA is a cytokine receptor involved in IL-31 signaling and is expressed on monocytes. It can function as a monomer or part of a receptor complex with OSMR, and activates pathways like STAT-3 and STAT-5.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lung
Immunohistochemical staining of human lung shows moderate cytoplasmic positivity in macrophages.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_3_4_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/986_C6_2_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/832_C6_4_red_green.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (GAMG, HBEC3-KT, HHSteC, hTERT-HME1, U-2 OS, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164509-IL31RA
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL31RA
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 31 receptor A
- Biological Process
- Immunity
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Cytosol
- Introduction
- The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
- Alternative Names
- CRL, CRL3, GLM-R, Glmr, IL-31RA
- Gene ID
- 133396
- UniProt ID
- Q8NI17
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Datasheet
MSDS
COA
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See other products for "IL31RA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-439CQ | Anti-Human IL31RA Recombinant Antibody (TAB-439CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-439CQ | Afuco™ Anti-IL31RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-439CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0130-YC | Mouse Anti-IL31RA Recombinant Antibody (HPAB-J0130-YC) | Inhib | Mouse IgG |
| HPAB-J0131-YC | Mouse Anti-IL31RA Recombinant Antibody (HPAB-J0131-YC) | Inhib, ELISA | Mouse IgG |
| HPAB-J0132-YC | Mouse Anti-IL31RA Recombinant Antibody (HPAB-J0132-YC) | Inhib | Mouse IgG |
| HPAB-J0133-YC | Mouse Anti-IL31RA Recombinant Antibody (HPAB-J0133-YC) | Inhib | Mouse IgG |
| HPAB-J0134-YC | Human Anti-IL31RA Recombinant Antibody (HPAB-J0134-YC) | Inhib | Chimeric (mouse/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0130-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0130-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0131-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0131-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0132-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0132-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0133-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0133-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0134-YC-S(P) | Human Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0134-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0130-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0130-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0131-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0131-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0132-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0132-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0133-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0133-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0134-YC-F(E) | Human Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0134-YC-F(E)) | ELISA, Inhib | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY129 | Human Anti-IL31RA scFv-Fc Chimera (VS-0425-FY129) | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3527 | Anti-IL31RA Immunohistochemistry Kit | IHC |
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