Anti-Human IL31RA Recombinant Antibody (TAB-439CQ) (CAT#: TAB-439CQ)
Recombinant monoclonal antibody to IL31RA. This antibody is a humanized monoclonal antibody that binds specifically to IL-31RA, blocking the interaction between IL-31 and its receptor.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/if_selected.jpg
Figure 2 IHC staining of human lung
(Immunohistochemical staining of human lung shows moderate cytoplasmic positivity in macrophages.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_3_4_selected.jpg
(Immunohistochemical staining of human lung shows moderate cytoplasmic positivity in macrophages.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_3_4_selected.jpg
Figure 3 IF staining of human cell line PC-3
(Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/986_C6_2_red_green.jpg
(Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/986_C6_2_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/832_C6_4_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/832_C6_4_red_green.jpg
Figure 5 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_9_8.jpg
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_9_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (GAMG, HBEC3-KT, HHSteC, hTERT-HME1, U-2 OS, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164509-IL31RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164509-IL31RA
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- IgG2, κ
- Specificity
- Human IL31RA
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, FuncS
- Conjugate
- Unconjugated
- Related Disease
- Atopic dermatitis, Pruritus
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The IL31RA antibody has been reported in applications of Neut, Inhib.
Inhibition: To investigate the inhibition of native IL‐31 signalling by nemolizumab, A549 cells were cultured in F‐12K medium (Life Technologies, Tokyo, Japan) containing 10% foetal bovine serum (FBS) and 100 units/mL penicillin‐100 μg/mL streptomycin in 24‐well plates) overnight. Next, the cells were treated with nemolizumab for 2 hours and then hIL‐31 was added. After incubation for 20 minutes, cells were lysed and the phosphorylation of STAT3 was analysed with the PathScan Phospho‐Stat3 (Tyr705) Sandwich ELISA Kit.
Target
- Alternative Names
- CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384
- Gene ID
- 133396
- UniProt ID
- Q8NI17
Related Resources
Please refer to Nemolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Nemolizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-168CQ | Mouse Anti-IL31RA Recombinant Antibody (clone YC131) | ELISA, WB, IF, IP | Mouse IgG2a, κ |
| MOB-175CQ | Human Anti-IL31RA Recombinant Antibody (MOB-175CQ) | ELISA, FC | Chimeric (mouse/human) IgG |
| HPAB-1243-FY | Human Anti-IL31RA Recombinant Antibody (HPAB-1243-FY) | Neut | Human IgG |
| HPAB-J0130-YC | Mouse Anti-IL31RA Recombinant Antibody (HPAB-J0130-YC) | Inhib | Mouse IgG |
| HPAB-J0131-YC | Mouse Anti-IL31RA Recombinant Antibody (HPAB-J0131-YC) | Inhib, ELISA | Mouse IgG |
Customer Reviews and Q&As
Customer Review
Q&As
Perfect for Flow Cytometry Applications
The antibody's compatibility with flow cytometry has made sorting IL31RA-expressing cells seamless. Its high binding affinity ensures clarity and precision, elevating our cell sorting experiments.
Reliable Across Various Sample Types
We've deployed this antibody in numerous sample types from tissue to cell lines, and the results have been consistently reliable, proving its adaptability in diverse research scenarios.
Crucial for Understanding Inflammatory Mechanisms
The insights gained from using this antibody in inflammation research have been significant. Its role in dissecting IL31RA-related pathways has pushed our research to new levels.
Versatile and Cost-effective
Given its wide applicability and robust performance, TAB-439CQ offers excellent value, providing cost-effectiveness alongside top-notch performance in our research.
Facilitates Deeper Insight into Immune Research
Especially in autoimmune and inflammatory disease models, this antibody allows deeper exploration into IL31RA's role, driving more insightful conclusions in our studies.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-439CQ, RRID: AB_3111945)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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