Recombinant Anti-JAG1 Vesicular Antibody, EV Displayed (VS-0425-YC326) (CAT#: VS-0425-YC326)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• JAG1

• Host Animal
• Mouse

• Antibody Isotype
• IgG

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Jagged canonical Notch ligand 1

• Biological Process
• Notch signaling pathway

• Molecular Function
• Developmental protein

• Cellular Localization
• Golgi apparatus, Plasma membrane

• Introduction
• The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

• Alternative Names
• AGS, AHD, AWS, CD339, HJ1, JAGL1

• Gene ID
• 182

• UniProt ID
• P78504

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