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    For Research Use Only. Not For Clinical Use.


    Background

    The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
    JAG1
    Protein class

    CD markers, Disease related genes, Human disease related genes, Plasma proteins

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Squamous epithelial cells, Basal squamous epithelial cells, Endometrial ciliated cells, Smooth muscle cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (HBEC3-KT, hTERT-HME1, U-251 MG)

    Interaction

    Interacts with NOTCH2 and NOTCH3 (By similarity). Interacts with NOTCH1 (in the presence of calcium ions) (PubMed:18660822).

    Molecular function

    Developmental protein

    More Types Infomation
    Related Signaling Pathways
    TNF Signaling Pathway TNF Signaling Pathway
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