Recombinant Rabbit Anti-LRP2 Antibody (clone 10B5) (CAT#: VS4-CJ20)
This rabbit anti-LRP2 antibody (clone 10B5) is a product that recognizes human LRP2. The immunogen of this antibody is a synthesized peptide derived from human LRP2. The mAb has been tested for use in ELISA, Flow Cytometry (1:50-1:200).
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/if_selected.jpg
Figure 2 IHC staining of human kidney
(High expression. RNA expression: 34.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/ihc_selected.jpg
(High expression. RNA expression: 34.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/ihc_selected.jpg
Figure 3 IHC staining of human lymph node
(Low expression. RNA expression: 0.0 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_8_8_val_selected.jpg
(Low expression. RNA expression: 0.0 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_8_8_val_selected.jpg
Figure 4 Cerebral cortex
(Glial cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_B_9_5.jpg
(Glial cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_B_9_5.jpg
Figure 5 Parathyroid gland
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_3_8.jpg
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_3_8.jpg
Figure 6 Liver
(Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_9_4.jpg
(Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_9_4.jpg
Figure 7 Kidney
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_7_5.jpg
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_7_5.jpg
Figure 8 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_4_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_4_6.jpg
Figure 9 RNA cell line category: Group enriched (AF22, CACO-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081479-LRP2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081479-LRP2
Specifications
- Immunogen
- A synthesized peptide derived from human LRP2
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human LRP2
- Species Reactivity
- Human
- Clone
- 10B5
- Applications
- ELISA, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Flow Cytometry (1:50-1:200).
Target
- Alternative Names
- DBS; GP330; LRP-2
- Gene ID
- 4036
- UniProt ID
- P98164
- Long Name
- LDL receptor related protein 2
- Sequence Similarities
- Belongs to the LDLR family.
- Cellular Localization
- Cell membrane, Cell projection, Coated pit, Endosome, Membrane
- Post Translation Modifications
- A fraction undergoes proteolytic cleavage of the extracellular domain at the cell membrane to generate a cytoplasmic tail fragment. This is internalized into the early endosome from where it trafficks in an LDLRAP1/ARH-dependent manner to the endocytic recycling compartment (ERC). In the ERC, it is further cleaved by gamma-secretase to release a fragment which translocates to the nucleus and mediates transcriptional repression.
- Protein Refseq
- NP_004516.2
- Function
- Multiligand endocytic receptor (By similarity).
Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity).
Mediates receptor-mediated uptake of polybasic drugs such as aminoglycosides and polymyxin B (By similarity).
In the kidney, mediates the tubular uptake and clearance of leptin (By similarity).
Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity).
Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity).
Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity).
Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity).
Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248).
Together with CUBN, mediates renal reabsorption of myoglobin (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "LRP2"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1789z | Mouse Anti-LRP2 Recombinant Antibody (clone 44H10) | ICC, IF, IHC | Mouse IgG1 |
| MOB-048CQ | Rabbit Anti-Human LRP2 Polyclonal Antibody | ELISA, WB | Rabbit IgG |
| VS3-XY3420 | Rabbit Anti-LRP2 Recombinant Antibody (clone R02-7D4) | WB | Rabbit IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2086 | Hi-Affi™ Recombinant Rabbit Anti-LRP2 Monoclonal Antibody (DS2086AB) | WB | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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