Recombinant Rabbit Anti-LRP2 Antibody (clone 10B5)
CAT#: VS4-CJ20
This rabbit anti-LRP2 antibody (clone 10B5) is a product that recognizes human LRP2. The immunogen of this antibody is a synthesized peptide derived from human LRP2. The mAb has been tested for use in ELISA, Flow Cytometry (1:50-1:200).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human kidney
High expression. RNA expression: 34.8 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human lymph node
Low expression. RNA expression: 0.0 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_8_8_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_B_9_5.jpg
Normal Tissue
Figure 5 Parathyroid gland
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_3_8.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Proximal tubules (microvilli)
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_4_6.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (AF22, CACO-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081479-LRP2
❮
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Specifications
- Immunogen
- A synthesized peptide derived from human LRP2
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human LRP2
- Species Reactivity
- Human
- Clone
- 10B5
- Applications
- ELISA, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Flow Cytometry (1:50-1:200).
Target
- Alternative Names
- DBS; GP330; LRP-2
- Gene ID
- 4036
- UniProt ID
- P98164
- Long Name
- LDL receptor related protein 2
- Sequence Similarities
- Belongs to the LDLR family.
- Cellular Localization
- Cell membrane, Cell projection, Coated pit, Endosome, Membrane
- Post Translation Modifications
- A fraction undergoes proteolytic cleavage of the extracellular domain at the cell membrane to generate a cytoplasmic tail fragment. This is internalized into the early endosome from where it trafficks in an LDLRAP1/ARH-dependent manner to the endocytic recycling compartment (ERC). In the ERC, it is further cleaved by gamma-secretase to release a fragment which translocates to the nucleus and mediates transcriptional repression.
- Protein Refseq
- NP_004516.2
- Function
- Multiligand endocytic receptor (By similarity).
Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity).
Mediates receptor-mediated uptake of polybasic drugs such as aminoglycosides and polymyxin B (By similarity).
In the kidney, mediates the tubular uptake and clearance of leptin (By similarity).
Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity).
Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity).
Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity).
Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity).
Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248).
Together with CUBN, mediates renal reabsorption of myoglobin (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
- CAT
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Recommended Dilution Buffer
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- Product Name
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