Recombinant Rabbit Anti-LRP2 Antibody (clone 10B5) (CAT#: VS4-CJ20)

• Immunogen
• A synthesized peptide derived from human LRP2

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human LRP2

• Species Reactivity
• Human

• Clone
• 10B5

• Applications
• ELISA, FC

• Conjugate
• Unconjugated

• Purification
• Affinity chromatography

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.

• Preservative
• 0.02% Sodium Azide

• Storage
• Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

• Application Notes
• This antibody has been tested for use in ELISA, Flow Cytometry (1:50-1:200).

• Alternative Names
• DBS; GP330; LRP-2

• Gene ID
• 4036

• UniProt ID
• P98164

• Long Name
• LDL receptor related protein 2

• Sequence Similarities
• Belongs to the LDLR family.

• Cellular Localization
• Cell membrane, Cell projection, Coated pit, Endosome, Membrane

• Post Translation Modifications
• A fraction undergoes proteolytic cleavage of the extracellular domain at the cell membrane to generate a cytoplasmic tail fragment. This is internalized into the early endosome from where it trafficks in an LDLRAP1/ARH-dependent manner to the endocytic recycling compartment (ERC). In the ERC, it is further cleaved by gamma-secretase to release a fragment which translocates to the nucleus and mediates transcriptional repression.

• Protein Refseq
• NP_004516.2

• Function
• Multiligand endocytic receptor (By similarity).
  Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity).
  Mediates receptor-mediated uptake of polybasic drugs such as aminoglycosides and polymyxin B (By similarity).
  In the kidney, mediates the tubular uptake and clearance of leptin (By similarity).
  Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity).
  Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity).
  Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity).
  Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity).
  Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248).
  Together with CUBN, mediates renal reabsorption of myoglobin (By similarity).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-057CQ
• Donkey Anti-Rabbit IgG (H&L) Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

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