Recombinant Anti-LYPD3 Vesicular Antibody, EV Displayed (VS-0425-YC487) (CAT#: VS-0425-YC487)
The Recombinant Anti-LYPD3 Vesicular Antibody, EV Displayed (VS-0425-YC487) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LYPD3-expressed cells or tissues. LYPD3 is involved in laminin binding and regulation of smooth muscle cell apoptosis. This protein is located extracellularly.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RT4
(Immunofluorescent staining of human cell line RT4 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77859/1748_H2_22_cr5805e03b68159_selected.jpg
(Immunofluorescent staining of human cell line RT4 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77859/1748_H2_22_cr5805e03b68159_selected.jpg
Figure 2 IHC staining of human skin
(High expression. RNA expression: 669.3 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41529/88166_B_7_1_val_selected.jpg
(High expression. RNA expression: 669.3 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41529/88166_B_7_1_val_selected.jpg
Figure 3 IHC staining of human kidney
(Low expression. RNA expression: 2.9 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41529/88166_A_8_5_val_selected.jpg
(Low expression. RNA expression: 2.9 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41529/88166_A_8_5_val_selected.jpg
Figure 4 IHC staining of human esophagus
(High expression. RNA expression: 1066.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_B_5_1_val_selected.jpg
(High expression. RNA expression: 1066.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_B_5_1_val_selected.jpg
Figure 5 IHC staining of human skeletal muscle
(Low expression. RNA expression: 2.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_B_2_6_val_selected.jpg
(Low expression. RNA expression: 2.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_B_2_6_val_selected.jpg
Figure 6 Cerebral cortex
(Neuronal cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranou)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_B_8_5.jpg
(Neuronal cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranou)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_B_8_5.jpg
Figure 7 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_A_7_3.jpg
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_A_7_3.jpg
Figure 8 Testis
(Leydig cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_A_6_6.jpg
(Leydig cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_A_6_6.jpg
Figure 9 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_A_8_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41797/88184_A_8_8.jpg
Figure 10 RNA cell line category: Cell line enhanced (CAPAN-2, HaCaT, MCF7, RT4, SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000124466-LYPD3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000124466-LYPD3
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LYPD3
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- LY6/PLAUR domain containing 3
- Cellular Localization
- Endoplasmic reticulum, Vesicles
- Introduction
- Predicted to enable laminin binding activity. Involved in negative regulation of smooth muscle cell apoptotic process. Located in extracellular space.
- Alternative Names
- C4.4A
- Gene ID
- 27076
- UniProt ID
- O95274
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2109 | Hi-Affi™ Recombinant Rabbit Anti-LYPD3 Monoclonal Antibody (DS2109AB) | ELISA | IgG |
| MOR-4318 | Hi-Affi™ Recombinant Rabbit Anti-LYPD3 Monoclonal Antibody (SI407DS) | FC | IgG |
| MOR-4319 | Hi-Affi™ Recombinant Rabbit Anti-LYPD3 Monoclonal Antibody (SI408DS) | WB, ELISA, ICC/IF, IF, FC | IgG |
| MOR-4320 | Hi-Affi™ Recombinant Rabbit Anti-LYPD3 Monoclonal Antibody (SI409DS) | FC | IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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