Recombinant Anti-NCSTN Vesicular Antibody, EV Displayed (VS-0425-YC138)
CAT#: VS-0425-YC138
The Recombinant Anti-NCSTN Vesicular Antibody, EV Displayed (VS-0425-YC138) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to NCSTN-expressed cells or tissues. The NCSTN is a type I transmembrane glycoprotein component of the gamma-secretase complex, participating in cleaving proteins like Notch receptors and amyloid precursor protein, with mutations linked to familial acne inversa.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70642/1351_B11_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54846/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human stomach
Immunohistochemical staining of human stomach shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21982/151332_A_5_1_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54846/139520_B_9_5.jpg
Normal Tissue
Figure 5 Cerebellum
Purkinje cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54846/139520_B_9_8.jpg
Normal Tissue
Figure 6 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54846/139520_A_9_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21982/151332_A_9_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54846/139520_A_7_5.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:
Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21982/151332_A_7_8.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162736-NCSTN
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- NCSTN
- Host Animal
- Human
- Antibody Isotype
- IgG
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Nicastrin
- Biological Process
- Notch signaling pathway
- Cellular Localization
- Cytosol
- Introduction
- This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
- Alternative Names
- APH2, KIAA0253
- Gene ID
- 23385
- UniProt ID
- Q92542
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Datasheet
MSDS
COA
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See other products for "NCSTN"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-694 | Recombinant Anti-human NCSTN Antibody | ELISA, IP, FuncS | IgG |
| MHH-694 | Recombinant Human Anti-human NCSTN Antibody | RIA, IF, FuncS | IgG |
| MOB-2454CT | Recombinant Mouse anti-Human NCSTN Monoclonal antibody (nBcdbn) | WB, IHC-P | |
| MRO-1095-CN | Recombinant Rabbit Anti-NCSTN Monoclonal Antibody (JG68-33) | WB | Rabbit IgG |
| VS3-FY1012 | Recombinant Rabbit Anti-NCSTN Antibody (clone R02-9E6) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-694-F(E) | Recombinant Anti-human NCSTN Antibody Fab Fragment | WB, ELISA, FuncS | Fab |
| MHH-694-F(E) | Recombinant Human Anti-human NCSTN Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-694-S(P) | Recombinant Anti-human NCSTN Antibody scFv Fragment | IF, FC, Biosensors, FuncS | scFv |
| MHH-694-S(P) | Recombinant Human Anti-human NCSTN Antibody scFv Fragment | WB, IF, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-479MZ | Anti-Human NCSTN Recombinant Antibody (A5201A) | ELISA, FuncS, ICC | Human antibody |
| TAB-479MZ-S(P) | Anti-Human NCSTN Recombinant Antibody scFv Fragment (A5201A) | IS | Human antibody |
| TAB-479MZ-F(E) | Anti-Human NCSTN Recombinant Antibody Fab Fragment (A5201A) | IS | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2386 | Hi-Affi™ Recombinant Rabbit Anti-NCSTN Monoclonal Antibody (DS2386AB) | WB, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1086 | AbPlus™ Anti-NCSTN Magnetic Beads (VS-0724-YC1086) | IP, Protein Purification | |
| VS-0724-YC1160 | AbPlus™ Anti-Ncstn Magnetic Beads (VS-0724-YC1160) | IP, Protein Purification |
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