Recombinant Anti-Nectin2 Vesicular Antibody, EV Displayed (VS-0425-YC681) (CAT#: VS-0425-YC681)
The Recombinant Anti-Nectin2 Vesicular Antibody, EV Displayed (VS-0425-YC681) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to Nectin2-expressed cells or tissues. Nectin2 enables ATP binding and is located in membranes, associated with diseases like Alzheimer's and multiple sclerosis.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73459/1409_E6_3_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73459/1409_E6_3_selected.jpg
Figure 2 Placenta
(Decidual cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_A_3_7.jpg
(Decidual cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_A_3_7.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_B_8_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_B_8_5.jpg
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_A_9_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_A_9_3.jpg
Figure 5 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_A_7_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_A_7_4.jpg
Figure 6 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_A_8_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_A_8_5.jpg
Figure 7 Testis
(Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_A_5_6.jpg
(Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12759/28705_A_5_6.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130202-Nectin2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130202-Nectin2
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- Nectin2
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Xenopus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Nectin cell adhesion molecule 2
- Biological Process
- Cell adhesion, Host-virus interaction
- Molecular Function
- Host cell receptor for virus entry, Receptor
- Cellular Localization
- Vesicles, Plasma membrane, Mitotic spindle
- Introduction
- Predicted to enable ATP binding activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human PVR (PVR cell adhesion molecule) and NECTIN2 (nectin cell adhesion molecule 2).
- Alternative Names
- cd111, cd112, clped1, ed4, higr, hveb, hvec, nectin-1, nectin-2, ofc7, prr, prr1, prr2, pvrl1, pvrl2, pvrr, pvrr1, pvrr2, sk-12
- Gene ID
- 448156
Downloads
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IgG Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAPAB-0338-CN | Recombinant Mouse Anti-Nectin2 Antibody | WB | Mouse IgG |
| MRO-1070-CN | Recombinant Rabbit Anti-NECTIN2 Monoclonal Antibody (JG39-64) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-WK496 | Rabbit Anti-NECTIN2 Recombinant Antibody (clone JG39-64) | WB, ELISA | Rabbit IgG |
| VS3-FY1020 | Recombinant Rabbit Anti-NECTIN2 Antibody (clone R07-7G6) | WB | Rabbit IgG |
| VS3-FY2044 | Rabbit Anti-NECTIN2 Recombinant Antibody (clone R06-8F3) | WB, IF, IP | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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