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Nectin2
Anti-Nectin2 Recombinant Antibody Products
- Recombinant Mouse Anti-Nectin2 Antibody (FAPAB-0338-CN)
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- Derivation: Serum
- Species Reactivity: Xenopus
- Type: Mouse IgG
- Application: WB
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- Mouse Anti-Nectin2 Antibody, mRNA (FAPAB-0338-CN-mRNA)
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- Species Reactivity: Xenopus
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
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- AbPlus™ Anti-NECTIN2 Magnetic Beads (VS-0724-YC1270) (VS-0724-YC1270)
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- Target: NECTIN2
- Target Species: Human
- Application: IP, Protein Purification
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- AbPlus™ Anti-Nectin2 Magnetic Beads (VS-0724-YC1308) (VS-0724-YC1308)
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- Target: Nectin2
- Target Species: Mouse
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Protein class
CD markers, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Pancreatic endocrine cells, Ductal cells, Exocrine glandular cells, Adipocytes, Glandular and luminal cells)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Low cell line specificity
Interaction
Can form trans-heterodimers with NECTIN3 (By similarity). Interacts with CD226 or with PVRIG; these interactions are competitive and have a differential functional outcome on T-cell activation, either positive or negative, respectively. Binds with low affinity to TIGIT. (Microbial infection) Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D (PubMed:11602758, PubMed:9657005).
Molecular function
Host cell receptor for virus entry, Receptor
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