Recombinant Anti-NGFR Vesicular Antibody, EV Displayed (VS-0425-YC590)
CAT#: VS-0425-YC590
The Recombinant Anti-NGFR Vesicular Antibody, EV Displayed (VS-0425-YC590) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to NGFR-expressed cells or tissues. NGFR is a nerve growth factor receptor with an extracellular domain containing cysteine-rich regions. It binds nerve growth factor, with implications in neuronal development.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4765/if_selected.jpg
Normal Tissue
Figure 2 Adrenal gland
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4765/15396_B_6_5_val_selected.jpg
Normal Tissue
Figure 3 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1995/5109_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/143/2551_A_9_5.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (RH-30, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000064300-NGFR
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- NGFR
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Monkey, Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Nerve growth factor receptor
- Biological Process
- Apoptosis, Biological rhythms, Differentiation, Neurogenesis
- Molecular Function
- Developmental protein, Receptor
- Cellular Localization
- Nucleoplasm, Plasma membrane
- Introduction
- Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
- Alternative Names
- CD271, p75NTR, TNFRSF16
- Gene ID
- 4804
- UniProt ID
- P08138
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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