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anti-Ngfr immunotoxin MC-192 (IgG)-Sap (AGTO-L038S)

This immunotoxin was achieved by conjugating/fusing the Anti-Ngfr monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to neurons and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Alzheimer's disease.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Rat
Clone
MC-192
Molecule Class
L kappa; IgG1-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Alzheimer's disease
Target
Alternative Names
NGFR; nerve growth factor receptor (TNFR superfamily, member 16); p75; LNGFR; p75NTR; p75NGFR; Tnfrsf16; tumor necrosis factor receptor superfamily member 16
Entrez Gene ID
18053
UniProt ID
Q8CFT3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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