anti-Ngfr immunotoxin MC-192 (IgG)-Sap

CAT#: AGTO-L038S

This immunotoxin was achieved by conjugating/fusing the Anti-Ngfr monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to neurons and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Alzheimer's disease.

Gene Expression
Figure 1 IF staining of human cell line U-2 OS Figure 2 Adrenal gland Figure 3 Colon Figure 4 Kidney Figure 5 RNA cell line category: Group enriched (RH-30, WM-115)

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Rat
  • Clone
  • MC-192
  • Molecule Class
  • L kappa; IgG1-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Alzheimer's disease

Target

  • Alternative Names
  • NGFR; nerve growth factor receptor (TNFR superfamily, member 16); p75; LNGFR; p75NTR; p75NGFR; Tnfrsf16; tumor necrosis factor receptor superfamily member 16; NGF receptor; p75 neurotrophin receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; Alzheimer's disease; saporin; saporin-6; saporin-S6; SAP
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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