Recombinant Anti-ORAI1 Vesicular Antibody, EV Displayed (VS-0425-YC293)
CAT#: VS-0425-YC293
The Recombinant Anti-ORAI1 Vesicular Antibody, EV Displayed (VS-0425-YC293) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ORAI1-expressed cells or tissues. The ORAI1 is a calcium channel subunit activated by STIM1, playing a critical role in T-cell calcium influx, with defects causing immune dysfunction.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human skin
Immunohistochemical staining of human skin shows membranous positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_A_8_3.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_A_6_6.jpg
Normal Tissue
Figure 5 Skin
Epidermal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_B_5_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (NB-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000276045-ORAI1
❮
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ORAI1
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ORAI calcium release-activated calcium modulator 1
- Biological Process
- Adaptive immunity, Calcium transport, Immunity, Ion transport, Transport
- Molecular Function
- Calcium channel, Calmodulin-binding, Ion channel
- Introduction
- The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
- Alternative Names
- CRACM1, FLJ14466, TMEM142A
- Gene ID
- 84876
- UniProt ID
- Q96D31
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Related Diseases
Primary Immunodeficiency
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0851CL | Rat Anti-ORAI1 Recombinant Antibody (TAB-0851CL) | FC, Inhib | Rat IgG2a, κ |
| TAB-0852CL | Rat Anti-ORAI1 Recombinant Antibody (TAB-0852CL) | FC, Inhib | Rat IgG2a, κ |
| TAB-0855CL | Mouse Anti-ORAI1 Recombinant Antibody (TAB-0855CL) | FuncS, FC, WB, Inhib | Mouse IgG |
| TAB-0856CL | Mouse Anti-ORAI1 Recombinant Antibody (TAB-0856CL) | FuncS, FC, WB, Inhib | Mouse IgG |
| TAB-0857CL | Mouse Anti-ORAI1 Recombinant Antibody (TAB-0857CL) | FuncS, FC, WB, Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0853CL | Human Anti-ORAI1 Recombinant Antibody (TAB-0853CL) | FC, Inhib | Chimeric (rat/human) IgG |
| TAB-0853CL-S(P) | Rat Anti-ORAI1 Recombinant Antibody; scFv Fragment (TAB-0853CL-S(P)) | FC | scFv |
| TAB-0854CL-S(P) | Rat Anti-ORAI1 Recombinant Antibody; scFv Fragment (TAB-0854CL-S(P)) | FC | scFv |
| TAB-0853CL-F(E) | Human Anti-ORAI1 Recombinant Antibody; Fab Fragment (TAB-0853CL-F(E)) | FC | Chimeric (rat/human) Fab |
| TAB-0854CL-F(E) | Human Anti-ORAI1 Recombinant Antibody; Fab Fragment (TAB-0854CL-F(E)) | FC | Chimeric (rat/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2550 | Hi-Affi™ Recombinant Rabbit Anti-ORAI1 Monoclonal Antibody (DS2550AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2096-CN | Rabbit Anti-ORAI1 Polyclonal Antibody (MRO-2096-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-0508-FY | Mouse Anti-ORAI1 Recombinant Antibody (HPAB-0508-FY) | ELISA, Inhib, Block, FuncS | Mouse IgG |
| HPAB-0509-FY | Mouse Anti-ORAI1 Recombinant Antibody (HPAB-0509-FY) | ELISA, Block, FC | Mouse IgG |
| VS13-YC861 | Rabbit Anti-ORAI1 Recombinant Antibody (VS13-YC861) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0508-FY-S(P) | Mouse Anti-ORAI1 Recombinant Antibody; scFv Fragment (HPAB-0508-FY-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-0509-FY-S(P) | Mouse Anti-ORAI1 Recombinant Antibody; scFv Fragment (HPAB-0509-FY-S(P)) | ELISA, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0508-FY-F(E) | Mouse Anti-ORAI1 Recombinant Antibody; Fab Fragment (HPAB-0508-FY-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-0509-FY-F(E) | Mouse Anti-ORAI1 Recombinant Antibody; Fab Fragment (HPAB-0509-FY-F(E)) | ELISA, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5097 | Anti-ORAI1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5098 | Anti-Mouse ORAI1 Immunohistochemistry Kit | IHC |
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