Recombinant Anti-ORAI1 Vesicular Antibody, EV Displayed (VS-0425-YC293) (CAT#: VS-0425-YC293)
The Recombinant Anti-ORAI1 Vesicular Antibody, EV Displayed (VS-0425-YC293) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ORAI1-expressed cells or tissues. The ORAI1 is a calcium channel subunit activated by STIM1, playing a critical role in T-cell calcium influx, with defects causing immune dysfunction.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human skin
(Immunohistochemical staining of human skin shows membranous positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/ihc_selected.jpg
(Immunohistochemical staining of human skin shows membranous positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/ihc_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_B_7_5.jpg
(Endothelial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_B_7_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_A_8_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_A_8_3.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_A_6_6.jpg
Figure 5 Skin
(Epidermal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_B_5_8.jpg
(Epidermal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16583/37073_B_5_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000276045-ORAI1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000276045-ORAI1
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ORAI1
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ORAI calcium release-activated calcium modulator 1
- Biological Process
- Adaptive immunity, Calcium transport, Immunity, Ion transport, Transport
- Molecular Function
- Calcium channel, Calmodulin-binding, Ion channel
- Introduction
- The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
- Alternative Names
- CRACM1, FLJ14466, TMEM142A
- Gene ID
- 84876
- UniProt ID
- Q96D31
Related Resources
Primary Immunodeficiency
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ORAI1"
Select a product category from the dropdown menu below to view related products.
Please select product type
Chimeric Antibody Products
Mouse Antibody Products
Rabbit Monoclonal Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0853CL | Human Anti-ORAI1 Recombinant Antibody (TAB-0853CL) | FC, Inhib | Chimeric (rat/human) IgG |
| TAB-0854CL | Human Anti-ORAI1 Recombinant Antibody (TAB-0854CL) | FC, Inhib | Chimeric (rat/human) IgG |
| TAB-0853CL-S(P) | Rat Anti-ORAI1 Recombinant Antibody; scFv Fragment (TAB-0853CL-S(P)) | FC | scFv |
| TAB-0854CL-S(P) | Rat Anti-ORAI1 Recombinant Antibody; scFv Fragment (TAB-0854CL-S(P)) | FC | scFv |
| TAB-0853CL-F(E) | Human Anti-ORAI1 Recombinant Antibody; Fab Fragment (TAB-0853CL-F(E)) | FC | Chimeric (rat/human) Fab |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0425-YC293. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
-2.png)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Block, Cyt, FuncS, Inhib
Application: ELISA, IHC, FC, WB, IF, IA
Application: WB, ELISA, IF
Application: ELISA, FC, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
