Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
+ Filter
Loading...
Custom Services order now ship next day

ORAI1

Recombinant Antibody Products Functional Antibody Products Formats

Anti-ORAI1 Recombinant Antibody Products

More Infomation

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

More Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Protein class

Disease related genes, Human disease related genes, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (dendritic cells, NK-cells, Theca cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (NB-4)

Interaction

Interacts with STIM1 and STIM2; this regulates channel activity (PubMed:17905723, PubMed:19249086, PubMed:24351972, PubMed:28219928, PubMed:27185316, PubMed:30481768). Interacts with CALM; this may displace STIM1 and STIM2 and might thereby modulate channel activity (PubMed:23109337). Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca(2+) (PubMed:20418871). Forms a complex with CRACR2A/EFCAB4B and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with ASPH (isoform 8) (PubMed:22586105). Interacts with SLC35G1 (PubMed:22084111). Interacts with UBQLN1 (PubMed:23307288). Interacts with ADCY8; interaction is calcium store depletion independent; interaction occurs in membrane raft; interaction increases markedly after store depletion; positively regulates SOCE-induced adenylate cyclase activity; contributes to the targeting of ADCY8 to discrete regions of the plasma membrane that are shielded from other calcium events (PubMed:22494970). Interacts with EFHB; the interaction takes place upon Ca(2+)-store depletion (PubMed:30481768). Interacts (via N- and C-termini) with ATP2C2 (via N-terminus); this interaction regulates Ca(2+) influx at the plasma membrane.

Molecular function

Calcium channel, Calmodulin-binding, Ion channel

More Types Infomation
Related Diseases
Primary Immunodeficiency Primary Immunodeficiency
  • 0
  • 0
Cart
    Inquiry
    Go to compare

    Go to compare