Recombinant Anti-PMEL Vesicular Antibody, EV Displayed (VS-0425-YC658)
CAT#: VS-0425-YC658
The Recombinant Anti-PMEL Vesicular Antibody, EV Displayed (VS-0425-YC658) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PMEL-expressed cells or tissues. PMEL is a melanocyte-specific type I transmembrane glycoprotein crucial in melanosome structure. It also serves as a melanoma-specific serum marker, with its mature form generated through complex posttranslational processing.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to endoplasmic reticulum & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/1898_C6_19_cr5ba8a6f6e250d_selected.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_4_6.jpg
Normal Tissue
Figure 4 Skin
Melanocytes
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_B_7_1.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185664-PMEL
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PMEL
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Cynomolgus, Mouse, Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Premelanosome protein
- Biological Process
- Melanin biosynthesis
- Cellular Localization
- Endoplasmic reticulum, Golgi apparatus
- Introduction
- This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker.
- Alternative Names
- D12S53E, gp100, HMB-45, HMB45, ME20, Pmel17, SI, SIL, SILV
- Gene ID
- 6490
- UniProt ID
- P40967
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "PMEL"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1280z | Mouse Anti-PMEL Recombinant Antibody (clone 21C9) | ICC, IF, IHC | Mouse IgG1 |
| HPAB-0046-LSX | Mouse Anti-PMEL Recombinant Antibody (HPAB-0046-LSX) | ELISA, WB, FC, IB, IF | Mouse Fab |
| HPAB-0047-LSX | Human Anti-PMEL Recombinant Antibody (HPAB-0047-LSX) | ELISA, WB, FC | Human IgG |
| ZG-0592F | Mouse Anti-PMEL Recombinant Antibody (clone HMB45) | IHC-P | Mouse IgG1 |
| VS-0723-WK139 | Human Anti-PMEL Recombinant Antibody (VS-0723-WK139) | FC | Chimeric (rabbit/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G051E | Anti-PMEL immunotoxin (Fab)-PE | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1047CL | Anti-Human PMEL Recombinant Antibody (A3F) | WB | |
| TAB-1048CL | Anti-Human PMEL Recombinant Antibody (G11B) | WB, FC, IHC | |
| TAB-1049CL | Anti-Human PMEL Recombinant Antibody (J7E) | WB | |
| TAB-1050CL | Mouse Anti-PMEL Recombinant Antibody (TAB-1050CL) | FC, FuncS | Mouse IgG |
| TAB-1051CL | Mouse Anti-PMEL Recombinant Antibody (TAB-1051CL) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2761 | Hi-Affi™ Recombinant Rabbit Anti-PMEL Monoclonal Antibody (DS2761AB) | IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0046-LSX-S(P) | Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0046-LSX-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0047-LSX-S(P) | Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0047-LSX-S(P)) | ELISA, WB, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0046-LSX-F(E) | Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0046-LSX-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-0047-LSX-F(E) | Human Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0047-LSX-F(E)) | ELISA, WB, FC | Chimeric Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF186 | H-2Db/HPV16 E7 (RAHYNIVTF) MHC Monomer | MHC Multimer | |
| MHC-YF214 | B*15:01/EBV EBNA4 (GQGGSPTAM) MHC Monomer | MHC Multimer | |
| MHC-YF225 | A*02:01/HPV16 E7 (YMLDLQPET) MHC Monomer | MHC Multimer | |
| MHC-YF295 | A*02:01/HPV E7 (YMLDLQPETT) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5512 | Anti-PMEL Immunohistochemistry Kit | IHC | |
| VS-0525-XY5513 | Anti-Mouse PMEL Immunohistochemistry Kit | IHC | |
| VS-0525-XY5514 | Anti-Rat PMEL Immunohistochemistry Kit | IHC |
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