Recombinant Anti-PMEL Vesicular Antibody, EV Displayed (VS-0425-YC658) (CAT#: VS-0425-YC658)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• PMEL

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Cynomolgus, Mouse, Rat

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Premelanosome protein

• Biological Process
• Melanin biosynthesis

• Cellular Localization
• Endoplasmic reticulum, Golgi apparatus

• Introduction
• This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker.

• Alternative Names
• D12S53E, gp100, HMB-45, HMB45, ME20, Pmel17, SI, SIL, SILV

• Gene ID
• 6490

• UniProt ID
• P40967

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