Recombinant Anti-PMEL Vesicular Antibody, EV Displayed (VS-0425-YC658)
CAT#: VS-0425-YC658
The Recombinant Anti-PMEL Vesicular Antibody, EV Displayed (VS-0425-YC658) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PMEL-expressed cells or tissues. PMEL is a melanocyte-specific type I transmembrane glycoprotein crucial in melanosome structure. It also serves as a melanoma-specific serum marker, with its mature form generated through complex posttranslational processing.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to endoplasmic reticulum & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/1898_C6_19_cr5ba8a6f6e250d_selected.jpg
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PMEL
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Cynomolgus, Mouse, Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Premelanosome protein
- Biological Process
- Melanin biosynthesis
- Cellular Localization
- Endoplasmic reticulum, Golgi apparatus
- Introduction
- This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker.
- Alternative Names
- D12S53E, gp100, HMB-45, HMB45, ME20, Pmel17, SI, SIL, SILV
- Gene ID
- 6490
- UniProt ID
- P40967
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-YC658. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PMEL"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1280z | Mouse Anti-PMEL Recombinant Antibody (clone 21C9) | ICC, IF, IHC | Mouse IgG1 |
| HPAB-0046-LSX | Mouse Anti-PMEL Recombinant Antibody (HPAB-0046-LSX) | ELISA, WB, FC, IB, IF | Mouse Fab |
| HPAB-0047-LSX | Human Anti-PMEL Recombinant Antibody (HPAB-0047-LSX) | ELISA, WB, FC | Human IgG |
| ZG-0592F | Mouse Anti-PMEL Recombinant Antibody (clone HMB45) | IHC-P | Mouse IgG1 |
| VS-0723-WK139 | Human Anti-PMEL Recombinant Antibody (VS-0723-WK139) | FC | Chimeric (rabbit/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G051E | Anti-PMEL immunotoxin (Fab)-PE | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1047CL | Anti-Human PMEL Recombinant Antibody (A3F) | WB | |
| TAB-1048CL | Anti-Human PMEL Recombinant Antibody (G11B) | WB, FC, IHC | |
| TAB-1049CL | Anti-Human PMEL Recombinant Antibody (J7E) | WB | |
| TAB-1050CL | Mouse Anti-PMEL Recombinant Antibody (TAB-1050CL) | FC, FuncS | Mouse IgG |
| TAB-1051CL | Mouse Anti-PMEL Recombinant Antibody (TAB-1051CL) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2761 | Hi-Affi™ Recombinant Rabbit Anti-PMEL Monoclonal Antibody (DS2761AB) | IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0046-LSX-S(P) | Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0046-LSX-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0047-LSX-S(P) | Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0047-LSX-S(P)) | ELISA, WB, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0046-LSX-F(E) | Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0046-LSX-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-0047-LSX-F(E) | Human Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0047-LSX-F(E)) | ELISA, WB, FC | Chimeric Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF186 | H-2Db/HPV16 E7 (RAHYNIVTF) MHC Monomer | MHC Multimer | |
| MHC-YF214 | B*15:01/EBV EBNA4 (GQGGSPTAM) MHC Monomer | MHC Multimer | |
| MHC-YF225 | A*02:01/HPV16 E7 (YMLDLQPET) MHC Monomer | MHC Multimer | |
| MHC-YF295 | A*02:01/HPV E7 (YMLDLQPETT) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5512 | Anti-PMEL Immunohistochemistry Kit | IHC | |
| VS-0525-XY5513 | Anti-Mouse PMEL Immunohistochemistry Kit | IHC | |
| VS-0525-XY5514 | Anti-Rat PMEL Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: SPR, Inhib, FuncS
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
