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PMEL
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
A*02:01/Human gp100 (mutant) (IMDQVPFSV) MHC Tetramer (MHC-LC002)
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- Class: Class I
- Antigen: gp100 (mutant)
- Antigen Species: Human
- Peptide: IMDQVPFSV
- Conjugate: BV421
A*02:01/Human gp100 (Wild) (ITDQVPFSV) MHC Tetramer (MHC-LC003)
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- Class: Class I
- Antigen: gp100 (Wild)
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: BV421
A*0201/Human gp100 (ITDQVPFSV) MHC Tetramer (MHC-LC774)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: ITDQVPFSV
A*0201/Human gp100 (IMDQVPFSV) MHC Tetramer (MHC-LC775)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: IMDQVPFSV
A*0201/Human gp100 (VLYRYGSFSV) MHC Tetramer (MHC-LC776)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: VLYRYGSFSV
PE-A*02:01/Human PMEL (YLAPGPVTA) MHC Tetramer (MHC-LC929)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLAPGPVTA
- Conjugate: PE
PE-A*02:01/Human PMEL (YLEPAPVTA) MHC Tetramer (MHC-LC932)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPAPVTA
- Conjugate: PE
PE-A*02:01/Human PMEL (YLEPGPVTV) MHC Tetramer (MHC-LC935)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTV
- Conjugate: PE
A*02:01/Human gp100 (YLEPGPVTA) MHC Tetramer (MHC-LC141)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTA
- Conjugate: PE
A*02:01/Human gp100 (YLEPGPVTA) MHC Tetramer (MHC-LC142)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTA
- Conjugate: APC
A*24:02/Human gp100-intron 4 (VYFFLPDHL) MHC Tetramer (MHC-LC153)
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- Class: Class I
- Antigen: gp100-intron 4
- Antigen Species: Human
- Peptide: VYFFLPDHL
- Conjugate: PE
A*24:02/Human gp100-intron 4 (VYFFLPDHL) MHC Tetramer (MHC-LC154)
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- Class: Class I
- Antigen: gp100-intron 4
- Antigen Species: Human
- Peptide: VYFFLPDHL
- Conjugate: APC
A*02:01/Human gp100 (KTWGQYWQV) MHC Tetramer (MHC-LC014)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: KTWGQYWQV
- Conjugate: BV421
H-2Db/Human gp100 (KVPRNQDWL) MHC Tetramer (MHC-LC099)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: KVPRNQDWL
- Conjugate: BV421
A*02:01/Human gp100 (mutant) (IMDQVPFSV) MHC Tetramer (MHC-LC100)
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- Class: Class I
- Antigen: gp100 (mutant)
- Antigen Species: Human
- Peptide: IMDQVPFSV
- Conjugate: PE
A*02:01/Human gp100 (mutant) (IMDQVPFSV) MHC Tetramer (MHC-LC101)
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- Class: Class I
- Antigen: gp100 (mutant)
- Antigen Species: Human
- Peptide: IMDQVPFSV
- Conjugate: APC
A*02:01/Human gp100 (ITDQVPFSV) MHC Tetramer (MHC-LC102)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: PE
A*02:01/Human gp100 (ITDQVPFSV) MHC Tetramer (MHC-LC103)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: APC
PE-DRB*01:01/Human PMEL (WNRQLYPEWTEAQRLD) MHC Tetramer (MHC-LC1802)
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- Class: Class II
- Antigen: gp100
- Antigen Species: Human
- Peptide: WNRQLYPEWTEAQRLD
- Conjugate: PE
APC-A*02:01/Human PMEL (YLAPGPVTA) MHC Tetramer (MHC-LC930)
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLAPGPVTA
- Conjugate: APC
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