PMEL

Anti-PMEL Products

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BV421-A*02:01/Human gp100 (mutant) (IMDQVPFSV) MHC Tetramer (MHC-LC002)
- Class: Class I
- Antigen: gp100 (mutant)
- Antigen Species: Human
- Peptide: IMDQVPFSV
- Conjugate: BV421
Compare

A*02:01/Human gp100 (Wild) (ITDQVPFSV) MHC Tetramer (MHC-LC003)
- Class: Class I
- Antigen: gp100 (Wild)
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: BV421
Compare

BV421-A*02:01/Human gp100 (KTWGQYWQV) MHC Tetramer (MHC-LC014)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: KTWGQYWQV
- Conjugate: BV421
Compare

PE-DRB*01:01/Human PMEL (WNRQLYPEWTEAQRLD) MHC Tetramer (MHC-LC1802)
- Class: Class II
- Antigen: gp100
- Antigen Species: Human
- Peptide: WNRQLYPEWTEAQRLD
- Conjugate: PE
Compare

APC-A*02:01/Human PMEL (YLAPGPVTA) MHC Tetramer (MHC-LC930)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLAPGPVTA
- Conjugate: APC
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APC-A*02:01/Human PMEL (YLEPAPVTA) MHC Tetramer (MHC-LC933)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPAPVTA
- Conjugate: APC
Compare

APC-A*02:01/Human PMEL (YLEPGPVTV) MHC Tetramer (MHC-LC936)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTV
- Conjugate: APC
Compare

BV421-A*02:01/Human PMEL (YLAPGPVTA) MHC Tetramer (MHC-LC931)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLAPGPVTA
- Conjugate: BV421
Compare

BV421-A*02:01/Human PMEL (YLEPAPVTA) MHC Tetramer (MHC-LC934)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPAPVTA
- Conjugate: BV421
Compare

BV421-A*02:01/Human PMEL (YLEPGPVTV) MHC Tetramer (MHC-LC937)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTV
- Conjugate: BV421
Compare

APC-DRB*01:01/Human PMEL (WNRQLYPEWTEAQRLD) MHC Tetramer (MHC-LC1803)
- Class: Class II
- Antigen: gp100
- Antigen Species: Human
- Peptide: WNRQLYPEWTEAQRLD
- Conjugate: APC
Compare

BV421-DRB*01:01/Human PMEL (WNRQLYPEWTEAQRLD) MHC Tetramer (MHC-LC1804)
- Class: Class II
- Antigen: gp100
- Antigen Species: Human
- Peptide: WNRQLYPEWTEAQRLD
- Conjugate: BV421
Compare

PE-A*02:01/Human PMEL (KTWGQYWQV) MHC Tetramer (MHC-LC2223)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: KTWGQYWQV
- Conjugate: PE
Compare

PE-A*02:01/Human PMEL (KTWGQYWQVL) MHC Tetramer (MHC-LC2224)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: KTWGQYWQVL
- Conjugate: PE
Compare

PE-A*02:01/Human PMEL (LLDGTATLRL) MHC Tetramer (MHC-LC2225)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LLDGTATLRL
- Conjugate: PE
Compare

PE-B*07:02/Human PMEL (TPAEVSIVV) MHC Tetramer (MHC-LC2544)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: TPAEVSIVV
- Conjugate: PE
Compare

APC-A*02:01/Human PMEL (ITDQVPFSV) MHC Tetramer (MHC-LC2457)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: APC
Compare

APC-A*02:01/Human PMEL (YLEPGPVTA) MHC Tetramer (MHC-LC2458)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: YLEPGPVTA
- Conjugate: APC
Compare

PE-B*35:01/Human PMEL (TPAEVSIVV) MHC Tetramer (MHC-LC2545)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: TPAEVSIVV
- Conjugate: PE
Compare

PE-B*07:02/Human PMEL (EPGPVTAQV) MHC Tetramer (MHC-LC2467)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: EPGPVTAQV
- Conjugate: PE
Compare

PE-B*51:01/Human PMEL (EPGPVTAQV) MHC Tetramer (MHC-LC2468)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: EPGPVTAQV
- Conjugate: PE
Compare

PE-B*54:01/Human PMEL (EPGPVTAQV) MHC Tetramer (MHC-LC2469)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: EPGPVTAQV
- Conjugate: PE
Compare

PE-DRB1*04:01/Human PMEL (EGDAFELTVSCQGGLPK) MHC Tetramer (MHC-LC3201)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: EGDAFELTVSCQGGLPK
- Conjugate: PE
Compare

PE-DRB1*04:04/Human PMEL (EGDAFELTVSCQGGLPK) MHC Tetramer (MHC-LC3202)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: EGDAFELTVSCQGGLPK
- Conjugate: PE
Compare

PE-DRB1*04:01/Human PMEL (EKVPVSEVMGTTLAEMSTPEAT) MHC Tetramer (MHC-LC3203)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: EKVPVSEVMGTTLAEMSTPEAT
- Conjugate: PE
Compare

PE-DRB1*04:04/Human PMEL (EKVPVSEVMGTTLAEMSTPEAT) MHC Tetramer (MHC-LC3204)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: EKVPVSEVMGTTLAEMSTPEAT
- Conjugate: PE
Compare

Mouse Anti-PMEL Recombinant Antibody (clone 21C9) (MOB-1280z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, IF, IHC
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Afuco™ Anti-Human PMEL ADCC Recombinant Antibody, ADCC Enhanced (AFC-700CL)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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PE-A*02:01/Human PMEL (TITDQVPFSV) MHC Tetramer (MHC-LC2227)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: TITDQVPFSV
- Conjugate: PE
Compare

PE-A*02:01/Human PMEL (VLYRYGSFSV) MHC Tetramer (MHC-LC2228)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: VLYRYGSFSV
- Conjugate: PE
Compare

PE-A*02:01/Human PMEL (YLEPGPVTA) MHC Tetramer (MHC-LC2229)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: YLEPGPVTA
- Conjugate: PE
Compare

Recombinant Human Anti-gp100 Soluble TCR (clone 296) (scTCR-294CQ-S(P))
- Species Reactivity: Human
- Epitope: YLEPGPVTA
- MHC: HLA-A2
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Recombinant Human Anti-gp100 Soluble TCR (scTCR-296CQ-S(P)) (scTCR-296CQ-S(P))
- Species Reactivity: Human
- Epitope: YLEPGPVTA
- MHC: HLA-A2
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Recombinant Mouse Anti-gp100 Soluble TCR (clone gp100(154)) (scTCR-298CQ-S(P))
- Species Reactivity: Human
- Epitope: KTWGQYWQV
- MHC: HLA-A*0201
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Recombinant Human Anti-gp100 Soluble TCR (clone L2G2) (scTCR-299CQ-S(P))
- Species Reactivity: Human
- Epitope: aa 209-217
- MHC: HLA-A*0201
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Recombinant Human Anti-gp100 Soluble TCR (clone MPD) (scTCR-300CQ-S(P))
- Species Reactivity: Human
- Epitope: YLEPGPVTA
- MHC: HLA-A*0201
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Recombinant Human Anti-gp100 Soluble TCR (clone PMEL17) (scTCR-301CQ-S(P))
- Species Reactivity: Human
- Epitope: YLEPGPVTA
- MHC: HLA-A2
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Recombinant Human Anti-gp100 Soluble TCR (clone R6C12) (scTCR-302CQ-S(P))
- Species Reactivity: Human
- Epitope: aa 209-217
- MHC: HLA-A*0201
Compare

PE-DRB1*04:01/Human PMEL (IYRRRLMKQDFSVPQLPHS) MHC Tetramer (MHC-LC3205)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: IYRRRLMKQDFSVPQLPHS
- Conjugate: PE
Compare

PE-DRB1*04:04/Human PMEL (IYRRRLMKQDFSVPQLPHS) MHC Tetramer (MHC-LC3206)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: IYRRRLMKQDFSVPQLPHS
- Conjugate: PE
Compare

PE-DRB1*04:04/Human PMEL (KRCLLHLAVIGALLAVGATKV) MHC Tetramer (MHC-LC3207)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: KRCLLHLAVIGALLAVGATKV
- Conjugate: PE
Compare

PE-DRB1*04:04/Human PMEL (LCQPVLPSPACQLVLHQILKGG) MHC Tetramer (MHC-LC3208)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LCQPVLPSPACQLVLHQILKGG
- Conjugate: PE
Compare

PE-DRB1*04:01/Human PMEL (MTPAEVSIVVLSGTTAAQVTTT) MHC Tetramer (MHC-LC3209)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: MTPAEVSIVVLSGTTAAQVTTT
- Conjugate: PE
Compare

PE-DRB1*04:04/Human PMEL (MTPAEVSIVVLSGTTAAQVTTT) MHC Tetramer (MHC-LC3210)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: MTPAEVSIVVLSGTTAAQVTTT
- Conjugate: PE
Compare

PE-DRB1*04:01/Human PMEL (PGPVTAQVVLQAAIPLTSCGSS) MHC Tetramer (MHC-LC3211)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: PGPVTAQVVLQAAIPLTSCGSS
- Conjugate: PE
Compare

PE-DRB1*04:04/Human PMEL (PGPVTAQVVLQAAIPLTSCGSS) MHC Tetramer (MHC-LC3212)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: PGPVTAQVVLQAAIPLTSCGSS
- Conjugate: PE
Compare

PE-DRB1*04:04/Human PMEL (VSGLSIGTGRAMLGTHTMEVTVY) MHC Tetramer (MHC-LC3215)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: VSGLSIGTGRAMLGTHTMEVTVY
- Conjugate: PE
Compare

PE-DRB1*04:01/Human PMEL (WNRQLYPEWTEAQRLD) MHC Tetramer (MHC-LC3216)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: WNRQLYPEWTEAQRLD
- Conjugate: PE
Compare

PE-DRB1*04:04/Human PMEL (WNRQLYPEWTEAQRLD) MHC Tetramer (MHC-LC3217)
- Class: Class II
- Antigen: PMEL
- Antigen Species: Human
- Peptide: WNRQLYPEWTEAQRLD
- Conjugate: PE
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Mouse Anti-PMEL Antibody (clone G11B), mRNA (TAB-1048CL-mRNA)
- Species Reactivity: Human
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Recombinant Mouse Anti-Human PMEL Antibody (clone IMB46) (MOB-0325MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC
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A*0201/Human gp100 (ITDQVPFSV) MHC Tetramer (MHC-LC774)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: ITDQVPFSV
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A*0201/Human gp100 (IMDQVPFSV) MHC Tetramer (MHC-LC775)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: IMDQVPFSV
Compare

A*0201/Human gp100 (VLYRYGSFSV) MHC Tetramer (MHC-LC776)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: VLYRYGSFSV
Compare

PE-A*02:01/Human PMEL (YLAPGPVTA) MHC Tetramer (MHC-LC929)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLAPGPVTA
- Conjugate: PE
Compare

PE-A*02:01/Human PMEL (YLEPAPVTA) MHC Tetramer (MHC-LC932)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPAPVTA
- Conjugate: PE
Compare

PE-A*02:01/Human PMEL (YLEPGPVTV) MHC Tetramer (MHC-LC935)
- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTV
- Conjugate: PE
Compare

APC-A*02:01/Human PMEL (AMLGTHTMEV) MHC Tetramer (MHC-LC2904)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: AMLGTHTMEV
- Conjugate: APC
Compare

PE-A*02:01/Human PMEL (AVIGALLAV) MHC Tetramer (MHC-LC2906)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: AVIGALLAV
- Conjugate: PE
Compare

PE-A*02:01/Human PMEL (FLRNQPLTFA) MHC Tetramer (MHC-LC2912)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: FLRNQPLTFA
- Conjugate: PE
Compare

APC-A*02:01/Human PMEL (HLAVIGALL) MHC Tetramer (MHC-LC2916)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: HLAVIGALL
- Conjugate: APC
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APC-A*02:01/Human PMEL (LMAVVLASL) MHC Tetramer (MHC-LC2923)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LMAVVLASL
- Conjugate: APC
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APC-A*02:01/Human PMEL (MLGTHTMEV) MHC Tetramer (MHC-LC2924)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: MLGTHTMEV
- Conjugate: APC
Compare

APC-A*02:01/Human PMEL (RLMKQDFSV) MHC Tetramer (MHC-LC2929)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: RLMKQDFSV
- Conjugate: APC
Compare

PE-A*02:01/Human PMEL (SLADTNSLA) MHC Tetramer (MHC-LC2931)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: SLADTNSLA
- Conjugate: PE
Compare

PE-A*02:01/Human PMEL (YLAEADLSYT) MHC Tetramer (MHC-LC2941)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: YLAEADLSYT
- Conjugate: PE
Compare

APC-A*03:01/Human PMEL (AVVLASLIYR) MHC Tetramer (MHC-LC3005)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: AVVLASLIYR
- Conjugate: APC
Compare

PE-A*11:01/Human PMEL (AVVLASLIYR) MHC Tetramer (MHC-LC3006)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: AVVLASLIYR
- Conjugate: PE
Compare

PE-B*07:02/Human PMEL (CPIGENSPL) MHC Tetramer (MHC-LC3007)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: CPIGENSPL
- Conjugate: PE
Compare

APC-A*03:01/Human PMEL (GTATLRLVK) MHC Tetramer (MHC-LC3008)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: GTATLRLVK
- Conjugate: APC
Compare

APC-A*03:01/Human PMEL (ALLAVGATK) MHC Tetramer (MHC-CN1142)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ALLAVGATK
- Conjugate: APC
Compare

FITC-A*03:01/Human PMEL (ALLAVGATK) MHC Tetramer (MHC-CN1143)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ALLAVGATK
- Conjugate: FITC
Compare

A*03:01/Human PMEL (ALLAVGATK) MHC Tetramer (MHC-CN1144)
- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ALLAVGATK
- Conjugate: Unconjugated
Compare

A*02:01/HPV E7 (YMLDLQPETT) MHC Monomer (MHC-YF295)
- Class: Class I
- Antigen: E7
- Antigen Species: HPV
- Peptide: YMLDLQPETT
- Conjugate: Biotin
Compare

Recombinant Human Anti-gp100 Soluble TCR (296) (ZIP-Fos/ZIP-Jun) (VS-0622-YF294)
- Species Reactivity: Human
- Epitope: YLEPGPVTA
- MHC: HLA-A2
Compare

Recombinant Human Anti-gp100 Soluble TCR (ZIP-Fos/ZIP-Jun) (VS-0622-YF295) (VS-0622-YF295)
- Species Reactivity: Human
- Epitope: WTWNRQLYPEWTEAQRLD
- MHC: HLA-DR4
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Recombinant Human Anti-gp100 Soluble TCR (gp100) (ZIP-Fos/ZIP-Jun) (VS-0622-YF296)
- Species Reactivity: Human
- Epitope: YLEPGPVTA
- MHC: HLA-A2
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Mouse Anti-PMEL Recombinant Antibody (TAB-1052CL) (TAB-1052CL)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0046-LSX-F(E)) (HPAB-0046-LSX-F(E))
- Species Reactivity: Human, Cynomolgus monkey, Mouse, Rat
- Type: Mouse Fab
- Application: ELISA, WB, FC
Compare

Human Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0047-LSX-F(E)) (HPAB-0047-LSX-F(E))
- Derivation: Chimeric
- Species Reactivity: Human, Cynomolgus monkey, Mouse, Rat
- Type: Chimeric Fab
- Application: ELISA, WB, FC
Compare

Anti-PMEL immunotoxin (Fab)-PE (AGTO-G051E)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Anti-Human PMEL Antibody, Research Grade Biosimilar (TAB-728CL)
- Species Reactivity: Human
- Type: Antibody
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Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0046-LSX-S(P)) (HPAB-0046-LSX-S(P))
- Species Reactivity: Human, Cynomolgus monkey, Mouse, Rat
- Type: Mouse scFv
- Application: ELISA, WB, FC
Compare

Anti-Human PMEL Recombinant Antibody (A3F) (TAB-1047CL)
- Application: WB
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Anti-Human PMEL Recombinant Antibody (G11B) (TAB-1048CL)
- Application: WB, FC, IHC
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Anti-Human PMEL Recombinant Antibody (J7E) (TAB-1049CL)
- Application: WB
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Mouse Anti-PMEL Recombinant Antibody (TAB-1050CL) (TAB-1050CL)
- Species Reactivity: Cynomolgus monkey, rat, and mouse
- Type: Mouse IgG
- Application: FC, FuncS
Compare

Mouse Anti-PMEL Recombinant Antibody (TAB-1051CL) (TAB-1051CL)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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Anti-Human PMEL Recombinant Antibody scFv Fragment (A3F) (TAB-1047CL-S(P))
- Application: IHC, WB, FC
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Anti-Human PMEL Recombinant Antibody scFv Fragment (G11B) (TAB-1048CL-S(P))
- Application: IHC, WB, FC
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Anti-Human PMEL Recombinant Antibody scFv Fragment (J7E) (TAB-1049CL-S(P))
- Application: IHC, WB, FC
Compare

Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (TAB-1050CL-S(P)) (TAB-1050CL-S(P))
- Species Reactivity: Cynomolgus monkey, rat, and mouse
- Type: Mouse scFv
- Application: FC
Compare

Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (TAB-1051CL-S(P)) (TAB-1051CL-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
Compare

Anti-Human PMEL Recombinant Antibody Fab Fragment (A3F) (TAB-1047CL-F(E))
- Application: IHC, WB, FC
Compare

Anti-Human PMEL Recombinant Antibody Fab Fragment (G11B) (TAB-1048CL-F(E))
- Application: IHC, WB, FC
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Anti-Human PMEL Recombinant Antibody Fab Fragment (J7E) (TAB-1049CL-F(E))
- Application: IHC, WB, FC
Compare

Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (TAB-1050CL-F(E)) (TAB-1050CL-F(E))
- Species Reactivity: Cynomolgus monkey, rat, and mouse
- Type: Mouse Fab
- Application: FC
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Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (TAB-1051CL-F(E)) (TAB-1051CL-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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Hi-Affi™ Recombinant Rabbit Anti-PMEL Monoclonal Antibody (DS2761AB) (MOR-2761)
- Derivation: Phage display library screening
- Type: IgG
- Application: IHC-P
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Anti-PMEL17 (31D1.6.7)-mc-vc-MMAE ADC (ADC-150LCT)
- Target: PMEL17
- Linker: mc-VC (maleimidocaproyl-valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
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For Research Use Only. Not For Clinical Use.

Background

This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker.