PMEL
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTV
- Conjugate: BV421
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: KTWGQYWQV
- Conjugate: PE
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPAPVTA
- Conjugate: BV421
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: APC
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- Class: Class II
- Antigen: gp100
- Antigen Species: Human
- Peptide: WNRQLYPEWTEAQRLD
- Conjugate: BV421
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLAPGPVTA
- Conjugate: BV421
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- Class: Class I
- Antigen: Mouse gp100
- Antigen Species: Mouse
- Peptide: EGSRNQDWL
- Conjugate: APC
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: PE
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTV
- Conjugate: APC
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- Class: Class I
- Antigen: Mouse gp100
- Antigen Species: Human
- Peptide: EGSRNQDWL
- Conjugate: PE
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- Class: Class I
- Antigen: gp100 (mutant)
- Antigen Species: Human
- Peptide: IMDQVPFSV
- Conjugate: APC
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPAPVTA
- Conjugate: APC
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- Class: Class II
- Antigen: gp100
- Antigen Species: Human
- Peptide: WNRQLYPEWTEAQRLD
- Conjugate: APC
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- Class: Class I
- Antigen: Human gp100
- Antigen Species: Human
- Peptide: KVPRNQDWL
- Conjugate: APC
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- Class: Class I
- Antigen: gp100 (mutant)
- Antigen Species: Human
- Peptide: IMDQVPFSV
- Conjugate: PE
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLAPGPVTA
- Conjugate: APC
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- Class: Class I
- Antigen: Human gp100
- Antigen Species: Human
- Peptide: KVPRNQDWL
- Conjugate: PE
Compare
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: KVPRNQDWL
- Conjugate: BV421
Compare
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- Class: Class II
- Antigen: gp100
- Antigen Species: Human
- Peptide: WNRQLYPEWTEAQRLD
- Conjugate: PE
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- Class: Class I
- Antigen: gp100-intron 4
- Antigen Species: Human
- Peptide: VYFFLPDHL
- Conjugate: APC
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTV
- Conjugate: PE
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: KTWGQYWQV
- Conjugate: BV421
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: VLYRYGSFSV
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- Class: Class I
- Antigen: gp100-intron 4
- Antigen Species: Human
- Peptide: VYFFLPDHL
- Conjugate: PE
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPAPVTA
- Conjugate: PE
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: IMDQVPFSV
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- Class: Class I
- Antigen: gp100 (Wild)
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: BV421
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTA
- Conjugate: APC
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLAPGPVTA
- Conjugate: PE
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: ITDQVPFSV
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: YLEPGPVTA
- Conjugate: PE
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- Class: Class I
- Antigen: gp100 (mutant)
- Antigen Species: Human
- Peptide: IMDQVPFSV
- Conjugate: BV421
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: TPAEVSIVV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: AVVLASLIYR
- Conjugate: APC
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ALNFPGSQK
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: TPAEVSIVV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: HLAVIGALL
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ALNFPGSQK
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: TPAEVSIVV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LPDGQVIWV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: GLGQVPLIV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ALLAVGATK
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: TPAEVSIVV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: AMLGTHTMEV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ALLAVGATK
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LPSPACQLV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: GPVTAQVVL
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ALLAVGATK
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ALDGGNKHFL
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LPSPACQLV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: GPVTAQVVL
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ALLAVGATK
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: YLEPGPVTA
- Conjugate: BV421
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LPKEACMEI
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: EPGPVTAQV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: YLEPGPVTA
- Conjugate: PE
Compare
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: VLYRYGSFSV
- Conjugate: APC
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LPKEACMEI
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: EPGPVTAQV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: VLYRYGSFSV
- Conjugate: PE
Compare
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LLDGTATLRL
- Conjugate: APC
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LPKEACMEI
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: EPGPVTAQV
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: KTWGQYWQV
- Conjugate: APC
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: TITDQVPFSV
- Conjugate: PE
Compare
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LPDGQVIWV
- Conjugate: PE
Compare
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: YLEPGPVTA
- Conjugate: APC
Compare
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: BV421
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LLDGTATLRL
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: LPDGQVIWV
- Conjugate: PE
Compare
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: ITDQVPFSV
- Conjugate: APC
Compare
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: KTWGQYWQVL
- Conjugate: PE
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- Class: Class I
- Antigen: PMEL
- Antigen Species: Human
- Peptide: KTWGQYWQV
- Conjugate: PE
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- Class: Class I
- Antigen: gp100
- Antigen Species: Human
- Peptide: KTWGQYWQV
- Conjugate: APC
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- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, IF, IHC
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- Species Reactivity: Human
- Type: Antibody
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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- Species Reactivity: Cynomolgus monkey, rat, and mouse
- Type: Mouse Fab
- Application: FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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- Species Reactivity: Cynomolgus monkey, rat, and mouse
- Type: Mouse scFv
- Application: FC
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- Species Reactivity: Cynomolgus monkey, rat, and mouse
- Type: Mouse IgG
- Application: FC, FuncS
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Target: PMEL17
- Linker: mc-VC (maleimidocaproyl-valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
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- Derivation: Phage display library screening
- Type: IgG
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.