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PMEL

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This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, Dot, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, FacS, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
FC, RIA, Biosensors, FuncS
Application:
IHC, WB, FC
Application:
IHC, WB, FC
Application:
IHC, WB, FC
Species Reactivity:
Cynomolgus monkey, rat, and mouse
Application:
FC
Application:
IHC, WB, FC
Application:
IHC, WB, FC
Application:
IHC, WB, FC
Species Reactivity:
Cynomolgus monkey, rat, and mouse
Application:
FC
Class:
Class I
Target:
gp100 (mutant)
Specificity:
Human
Peptide:
IMDQVPFSV
Conjugate:
BV421
Class:
Class I
Target:
gp100 (Wild)
Specificity:
Human
Peptide:
ITDQVPFSV
Conjugate:
BV421
Class:
Class I
Target:
gp100
Specificity:
Human
Peptide:
KTWGQYWQV
Conjugate:
BV421
Class:
Class I
Target:
gp100
Specificity:
Human
Peptide:
KVPRNQDWL
Conjugate:
BV421
Class:
Class I
Target:
gp100 (mutant)
Specificity:
Human
Peptide:
IMDQVPFSV
Conjugate:
PE
Class:
Class I
Target:
gp100 (mutant)
Specificity:
Human
Peptide:
IMDQVPFSV
Conjugate:
APC
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