BV421-A*02:01/Human gp100 (KTWGQYWQV) MHC Tetramer (CAT#: MHC-LC014)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of gp100-derived peptide of KTWGQYWQV sequence covering 154-162 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • gp100
  • Antigen Species
  • Human
  • Peptide
  • KTWGQYWQV
  • Range
  • 154-162
  • Conjugate
  • BV421
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • PMEL; premelanosome protein; P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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