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    Anti-PMEL immunotoxin (Fab)-PE (CAT#: AGTO-G051E)

    This immunotoxin was achieved by conjugating/fusing the Anti-PMEL Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating Human melanoma Xenografts.

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    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line SK-MEL-30
    Figure 1 IF staining of human cell line SK-MEL-30
    (Immunofluorescent staining of human cell line SK-MEL-30 shows localization to endoplasmic reticulum & the Golgi apparatus.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/1898_C6_19_cr5ba8a6f6e250d_selected.jpg
    Normal Tissue
    Figure 2 Kidney
    Figure 2 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_7_5.jpg
    Figure 3 Testis
    Figure 3 Testis
    (Leydig cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_4_6.jpg
    Figure 4 Skin
    Figure 4 Skin
    (Melanocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_B_7_1.jpg
    RNA Expression
    Figure 5 RNA cell line category: Cell line enriched (SK-MEL-30)
    Figure 5 RNA cell line category: Cell line enriched (SK-MEL-30)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185664-PMEL

    Specifications

    • Host Species
    • Mouse
    • Species Reactivity
    • Human
    • Molecule Class
    • Fab-PE
    • Toxin Description
    • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
    • Applications
    • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
    • Related Disease
    • Human Melanoma Xenografts

    Target

    • Alternative Names
    • PMEL; premelanosome protein; P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E; melanocyte protein PMEL; melanocyte protein mel 17; silver, mouse, homolog of; melanocyte protein Pmel 17; melanosomal matrix protein17; silver locus protein homolog; melanoma-associated ME20 antigen; melanocytes lineage-specific antigen GP100; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE77

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

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    CAT Product Name Application Type
    TAB-1047CL-F(E) Anti-Human PMEL Recombinant Antibody Fab Fragment (A3F) IHC, WB, FC
    TAB-1048CL-F(E) Anti-Human PMEL Recombinant Antibody Fab Fragment (G11B) IHC, WB, FC
    TAB-1049CL-F(E) Anti-Human PMEL Recombinant Antibody Fab Fragment (J7E) IHC, WB, FC
    TAB-1050CL-F(E) Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (TAB-1050CL-F(E)) FC Mouse Fab
    TAB-1051CL-F(E) Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (TAB-1051CL-F(E)) FC Mouse Fab

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