Creative Biolabs Recombinant Antibodies
Products
  1. Home
  2. PMEL
  3. Anti-PMEL immunotoxin (Fab)-PE

Anti-PMEL immunotoxin (Fab)-PE (AGTO-G051E)

This immunotoxin was achieved by conjugating/fusing the Anti-PMEL Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating Human melanoma Xenografts.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Molecule Class
Fab-PE
Toxin Description
Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Human Melanoma Xenografts
Target
Alternative Names
PMEL; premelanosome protein; P1; SI; SIL; ME20; P100; SILV
Entrez Gene ID
6490
UniProt ID
P40967

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

See other products for "PMEL"
PE-A*02:01/Human PMEL (KTWGQYWQVL) MHC Tetramer    ( MHC-LC2224 )
H-2Db/Human gp100 (KVPRNQDWL) MHC Tetramer    ( MHC-LC099 )
A*02:01/Human gp100 (KTWGQYWQV) MHC Tetramer    ( MHC-LC105 )
Recombinant Chimeric Anti-PMEL Antibody (ch17A9)    ( HPAB-0047-LSX )
A*02:01/Human gp100 (mutant) (IMDQVPFSV) MHC Tetramer    ( MHC-LC100 )
Recombinant Mouse Anti-Human PMEL Antibody (clone IMB46)    ( MOB-0325MZ )
Recombinant Mouse Anti-gp100 Soluble TCR (clone T2(1)J)    ( scTCR-323CQ-S(P) )
Recombinant Mouse Anti-gp100 Soluble TCR (clone Sp(0.01)A)    ( scTCR-303CQ-S(P) )
>> MORE
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Increase Efficiency to Accelerate Your Research & Discovery Process

Increase Efficiency to Accelerate Your Research & Discovery Process

Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. Our service portfolio includes mouse and rat monoclonal antibody production ...

Find out more >

USA

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356

Europe

Tel: 44-207-097-1828
Email:
Follow us on:
           

Terms of Service-Privacy Policy     © 2007 - 2019 Creative-Biolabs All Rights Reserved