Recombinant Anti-PTPRB Vesicular Antibody, EV Displayed (VS-0425-YC185)
CAT#: VS-0425-YC185
The Recombinant Anti-PTPRB Vesicular Antibody, EV Displayed (VS-0425-YC185) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PTPRB-expressed cells or tissues. The PTPRB is a protein part of the protein tyrosine phosphatase family, regulating processes such as cell growth and differentiation. This receptor-type PTP interacts with sodium channels and plays roles in cell adhesion and neuronal differentiation.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67868/1717_A6_22_cr57f514fc87452_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4782/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67868/1315_H7_2_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67868/1287_H7_1_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4782/11835_B_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4782/11671_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4782/11671_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000127329-PTPRB
❮
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PTPRB
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Protein tyrosine phosphatase receptor type B
- Biological Process
- Angiogenesis
- Molecular Function
- Hydrolase, Protein phosphatase
- Cellular Localization
- Plasma membrane, Vesicles, Cell Junctions
- Introduction
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation.
- Alternative Names
- PTPB
- Gene ID
- 5787
- UniProt ID
- P23467
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Datasheet
MSDS
COA
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See other products for "PTPRB"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3104z | Mouse Anti-PTPRB Recombinant Antibody (clone 7C10) | ICC, IF | Mouse IgG2a |
| MRO-1296-CN | Recombinant Mouse Anti-PTPRB Monoclonal Antibody (2-A2) | IF, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-292CT | Human Anti-PTPRB Recombinant Antibody (TAB-292CT) | ELISA, FC | Human IgG |
| TAB-292CT-S(P) | Human Anti-PTPRB Recombinant Antibody; scFv Fragment (TAB-292CT-S(P)) | ELISA, FC | Human scFv |
| TAB-292CT-F(E) | Human Anti-PTPRB Recombinant Antibody; Fab Fragment (TAB-292CT-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS1-YJ199 | Mouse Anti-Ptprb Recombinant Antibody (clone 122.2) | IF, ICC, WB, IP | Mouse IgM |
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