Recombinant Anti-PTPRC Vesicular Antibody, EV Displayed (VS-0425-YC529)
CAT#: VS-0425-YC529
The Recombinant Anti-PTPRC Vesicular Antibody, EV Displayed (VS-0425-YC529) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PTPRC-expressed cells or tissues. PTPRC is a protein tyrosine phosphatase involved in T- and B-cell signaling. It interacts directly with antigen receptor complexes or activates kinases required for signaling. PTPRC is also a regulator of cytokine receptor signaling.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/if_selected.jpg
Normal Tissue
Figure 2 Appendix
Lymphoid tissue
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_3_2.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (Daudi, HEL, HL-60, JURKAT, MOLT-4, THP-1, U-266/70, U-266/84, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081237-PTPRC
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PTPRC
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Protein tyrosine phosphatase receptor type C
- Biological Process
- Host-virus interaction
- Molecular Function
- Hydrolase, Protein phosphatase
- Cellular Localization
- Nucleoplasm, Vesicles
- Introduction
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.
- Alternative Names
- CD45, GP180, LCA, T200
- Gene ID
- 5788
- UniProt ID
- P08575
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0365-CN-F(E) | Rabbit Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0365-CN-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-0366-CN-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0366-CN-F(E)) | ELISA, FC | Humanized Fab |
| FAMAB-0006-CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone LT40); Fab Fragment | FC | Mouse Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| NS-023CN-S(P) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); scFv Fragment | FC, IF | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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