CytoStream™ Rabbit Anti-PTPRC Recombinant Antibody (VS13-YC960)
CAT#: VS13-YC960
The CytoStream™ Rabbit Anti-PTPRC Recombinant Antibody is specific for human PTPRC. PTPRC encodes a receptor-type phosphatase crucial for antigen receptor signaling in lymphocyte activation. The anti-PTPRC antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/if_selected.jpg
Normal Tissue
Figure 2 Appendix
Lymphoid tissue
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_3_2.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (Daudi, HEL, HL-60, JURKAT, MOLT-4, THP-1, U-266/70, U-266/84, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081237-PTPRC
❮
❯
Specifications
- Immunogen
- Recombinant human CD45, aa 1210-1306.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human PTPRC
- Species Reactivity
- Human
- Applications
- WB, IHC-P, FC
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- CD45
- Gene ID
- 5788
- UniProt ID
- P08575
- Long Name
- Protein Tyrosine Phosphatase Receptor Type C
- Sequence Similarities
- Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
- Cellular Localization
- Cell junction; Cell membrane
- Protein Refseq
- NP_002829.3; NP_563578.2
- Function
- Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "PTPRC"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-240LC | Anti-Human PTPRC Recombinant Antibody (VHE/humV1) | Inhib | Humanized antibody |
| TAB-241LC | Anti-Human PTPRC Recombinant Antibody (VHE/humV2) | Inhib | Humanized antibody |
| TAB-240LC-F(E) | Anti-Human PTPRC Recombinant Antibody Fab Fragment (VHE/humV1) | ELISA, FC | Humanized antibody |
| TAB-241LC-F(E) | Anti-Human PTPRC Recombinant Antibody Fab Fragment (VHE/humV2) | ELISA, FC | Humanized antibody |
| TAB-242LC-F(E) | Anti-Human PTPRC Recombinant Antibody Fab Fragment (VHQ/humV1) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-245LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-245LC-F(E)) | ELISA, FC | Human Fab |
| TAB-246LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-246LC-F(E)) | ELISA, FC | Human Fab |
| TAB-247LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-247LC-F(E)) | ELISA, FC | Human Fab |
| TAB-248LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-248LC-F(E)) | ELISA, FC | Human Fab |
| TAB-249LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-249LC-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0466MZ | Chicken Anti-PTPRC Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1895CQ | Recombinant Mouse Anti-PTPRC Antibody (HI30) | WB, IP, IHC-Fr, FuncS, ICC, FC, IHC-P, BL | IgG1 |
| NEUT-1896CQ | Recombinant Mouse Anti-Ptprc Antibody (104-2) | FC, IP, BL, IHC-Fr, ICC, IF | IgG2a, κ |
| NEUT-1897CQ | Recombinant Rat Anti-Ptprc Antibody (MAB0822) | BL, FC, IP, WB | IgG2 |
| NEUT-1898CQ | Recombinant Rat Anti-Ptprc Antibody (RA3-6B2) | FC, IHC-Fr, IHC-P, IP, WB, BL | IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2933 | Hi-Affi™ Recombinant Rabbit Anti-PTPRC Monoclonal Antibody (DS2933AB) | IP, WB | IgG |
| MOR-0089-FY | Rabbit Anti-PTPRC Recombinant Antibody (clone AFY0060) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0365-CN-S(P) | Rabbit Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0365-CN-S(P)) | ELISA, FC | Rabbit scFv |
| HPAB-0366-CN-S(P) | Human Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0366-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-M0191-YC-S(P) | Human Anti-PTPRC Recombinant Antibody (clone M/YC-14); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-0536-FY-S(P) | Human Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0536-FY-S(P)) | Inhib, FuncS | Human scFv |
| HPAB-0537-FY-S(P) | Mouse Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0537-FY-S(P)) | FC, Block | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-081LC | Recombinant Mouse Anti-Sheep CD45 Antibody | FC, IP | Mouse IgG |
| HPAB-0536-FY | Human Anti-PTPRC Recombinant Antibody (HPAB-0536-FY) | Inhib, FuncS | Human IgG |
| HPAB-0537-FY | Mouse Anti-PTPRC Recombinant Antibody (HPAB-0537-FY) | FC, Block, FuncS | Mouse IgG |
| ZG-0116J | Mouse Anti-PTPRC Recombinant Antibody (ZG-0116J) | IHC-P, IF | Mouse IgG |
| ZG-0117J | Mouse Anti-PTPRC Recombinant Antibody (ZG-0117J) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-023CN | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4) | FC, IF | Mouse IgG1, κ |
| NS-023CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); Fab Fragment | FC, IF | Mouse Fab |
| NS-023CN-S(P) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); scFv Fragment | FC, IF | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0006-CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone LT40); Fab Fragment | FC | Mouse Fab |
| HPAB-0258-FY-F(E) | Mouse Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0258-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-M0191-YC-F(E) | Human Anti-PTPRC Recombinant Antibody (clone M/YC-14); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0536-FY-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0536-FY-F(E)) | Inhib, FuncS | Human Fab |
| HPAB-0537-FY-F(E) | Mouse Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0537-FY-F(E)) | FC, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY220 | AbPlus™ Anti-PTPRC Magnetic Beads (YTH54.12) | IP, Protein Purification | |
| VS-0724-YC1181 | AbPlus™ Anti-PTPRC Magnetic Beads (VS-0724-YC1181) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY98 | Mouse Anti-NHP PTPRC Recombinant Antibody (clone MEM55) | IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY185 | CytoStream™ Rat Anti-PTPRC Recombinant Antibody (clone 30-F11) | FC | Rat IgG2b, kappa |
| VS-0225-XY186 | CytoStream™ Mouse Anti-PTPRC Recombinant Antibody (clone OX-33) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY86 | Human Anti-PTPRC (clone VHE-N73D/humV1) scFv-Fc Chimera | IF, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC529 | Recombinant Anti-PTPRC Vesicular Antibody, EV Displayed (VS-0425-YC529) | ELISA, FC, Neut, Cell-uptake |
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