Recombinant Rabbit Anti-SCIN Antibody (clone 12B11) (CAT#: VS4-CJ107)
This rabbit anti-SCIN antibody (clone 12B11) is a product that recognizes human SCIN. The immunogen of this antibody is a synthesized peptide derived from human SCIN. The mAb has been tested for use in ELISA, Immunohistochemistry (1:50-1:200).
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Specifications
- Immunogen
- A synthesized peptide derived from human SCIN
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SCIN
- Species Reactivity
- Human
- Clone
- 12B11
- Applications
- ELISA, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Immunohistochemistry (1:50-1:200).
Target
- Alternative Names
- Scinderin
- Gene ID
- 85477
- UniProt ID
- Q9Y6U3
- Long Name
- Scinderin
- Sequence Similarities
- Belongs to the villin/gelsolin family.
- Cellular Localization
- Cell junction, Cell projection, Cytoplasm, Cytoskeleton
- Protein Refseq
- NP_001106177.1; NP_149119.1
- Function
- Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202).
Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity).
In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009).
Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity).
Regulates chondrocyte proliferation and differentiation (By similarity).
Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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