Recombinant Rabbit Anti-SCIN Antibody (clone 12B11)
CAT#: VS4-CJ107
This rabbit anti-SCIN antibody (clone 12B11) is a product that recognizes human SCIN. The immunogen of this antibody is a synthesized peptide derived from human SCIN. The mAb has been tested for use in ELISA, Immunohistochemistry (1:50-1:200).
Specifications
- Immunogen
- A synthesized peptide derived from human SCIN
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SCIN
- Species Reactivity
- Human
- Clone
- 12B11
- Applications
- ELISA, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Immunohistochemistry (1:50-1:200).
Target
- Alternative Names
- Scinderin
- Gene ID
- 85477
- UniProt ID
- Q9Y6U3
- Long Name
- Scinderin
- Sequence Similarities
- Belongs to the villin/gelsolin family.
- Cellular Localization
- Cell junction, Cell projection, Cytoplasm, Cytoskeleton
- Protein Refseq
- NP_001106177.1; NP_149119.1
- Function
- Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202).
Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity).
In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009).
Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity).
Regulates chondrocyte proliferation and differentiation (By similarity).
Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "SCIN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6382 | Anti-SCIN Immunohistochemistry Kit | IHC |
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