Recombinant Mouse Anti-SDCBP Antibody (clone 2A3E2) (CAT#: VS4-CJ108)
This mouse anti-SDCBP antibody (clone 2A3E2) is a product that recognizes human SDCBP. The immunogen of this antibody is recombinant human Syntenin-1 protein (2aa-298aa). This product was purified by protein G purified and it has been tested for use in ELISA, Western Blot (1:1000-1:5000).
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/if_selected.jpg
Figure 2 IHC staining of human prostate
(Immunohistochemical staining of human prostate shows strong positivity in peripheral nerves.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/ihc_selected.jpg
(Immunohistochemical staining of human prostate shows strong positivity in peripheral nerves.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/ihc_selected.jpg
Figure 3 IHC staining of human vulva/anal skin
(Immunohistochemical staining of human vulva/anal skin shows distinct cytoplasmic positivity in melanocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/ihc_selected.jpg
(Immunohistochemical staining of human vulva/anal skin shows distinct cytoplasmic positivity in melanocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/ihc_selected.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/241_E2_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/241_E2_1_red_green.jpg
Figure 5 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/239_E2_1_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/239_E2_1_red_green.jpg
Figure 6 Cerebral cortex
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_8_5.jpg
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_8_5.jpg
Figure 7 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_7_3.jpg
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_7_3.jpg
Figure 8 Skin
(Epidermal cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_5_8.jpg
(Epidermal cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_5_8.jpg
Figure 9 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_9_8.jpg
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_9_8.jpg
Figure 10 RNA cell line category: Cell line enhanced (HHSteC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137575-SDCBP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137575-SDCBP
Specifications
- Immunogen
- Recombinant Human Syntenin-1 protein (2aa-298aa)
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human SDCBP
- Species Reactivity
- Human
- Clone
- 2A3E2
- Applications
- ELISA, WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, PBS, pH 7.3.
- Preservative
- 0.1% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:1000-1:5000).
Target
- Alternative Names
- ST1; MDA9; SYCL; MDA-9; TACIP18
- Gene ID
- 6386
- UniProt ID
- O00560
- Long Name
- Syndecan binding protein
- Cellular Localization
- Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus, Secreted
- Post Translation Modifications
- Phosphorylated on tyrosine residues.
- Protein Refseq
- NP_001007068.1; NP_001007069.1; NP_001007070.1
- Function
- Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527).
Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292).
In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).
Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120).
In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591).
May also play a role in vesicular trafficking (PubMed:11179419).
Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
Recommended Products
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1089-VHH | Recombinant Anti-human SDCBP VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
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