Mouse Anti-SDCBP Recombinant Antibody (VS7-0425-WR834) (CAT#: VS7-0425-WR834)
This product is a mouse IgG antibody that binds to human SDCBP. The antibody can be used for WB assay. It cross reacts with rat, dog, and pig.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/if_selected.jpg

(Immunohistochemical staining of human prostate shows strong positivity in peripheral nerves.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/ihc_selected.jpg

(Immunohistochemical staining of human vulva/anal skin shows distinct cytoplasmic positivity in melanocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/ihc_selected.jpg

(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/241_E2_1_red_green.jpg

(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/239_E2_1_red_green.jpg

(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_8_5.jpg

(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_7_3.jpg

(Epidermal cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_5_8.jpg

(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_9_8.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137575-SDCBP
Specifications
- Immunogen
- Recombinant human SDCBP fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human SDCBP
- Species Reactivity
- Human, Rat, Dog, Pig
- Molecule Class
- Pdz-Domain-Containing Protein
- Applications
- WB
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis, Ascitic fluid
- Format
- Liquid
- Concentration
- 1 mg/ml
- Buffer
- 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl)
- Preservative
- 0.2% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:1000 - 1:2000
Target
- Alternative Names
- ST1; MDA9; SYCL; MDA-9; TACIP18
- Gene ID
- 6386
- UniProt ID
- O00560
- Long Name
- Syndecan Binding Protein
- Cellular Localization
- Cell junction; Cell membrane; Cytoplasm; Cytoskeleton; Endoplasmic reticulum; Membrane; Nucleus; Secreted
- Post Translation Modifications
- Acetylation; Phosphoprotein
- Protein Refseq
- NP_001007068.1
- Function
- Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527).; Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292).; In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).; Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120).; In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591).; May also play a role in vesicular trafficking (PubMed:11179419).; Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "SDCBP"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1089-VHH | Recombinant Anti-human SDCBP VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
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