Mouse Anti-SDCBP Recombinant Antibody (VS7-0425-WR834)
CAT#: VS7-0425-WR834
This product is a mouse IgG antibody that binds to human SDCBP. The antibody can be used for WB assay. It cross reacts with rat, dog, and pig.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, nuclear membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong positivity in peripheral nerves.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human vulva/anal skin
Immunohistochemical staining of human vulva/anal skin shows distinct cytoplasmic positivity in melanocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nuclear membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/241_E2_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 5 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nuclear membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/239_E2_1_red_green.jpg
Normal Tissue
Figure 6 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_8_5.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_7_3.jpg
Normal Tissue
Figure 8 Skin
Epidermal cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_5_8.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (HHSteC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137575-SDCBP
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Specifications
- Immunogen
- Recombinant human SDCBP fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human SDCBP
- Species Reactivity
- Human, Rat, Dog, Pig
- Molecule Class
- Pdz-Domain-Containing Protein
- Applications
- WB
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis, Ascitic fluid
- Format
- Liquid
- Concentration
- 1 mg/ml
- Buffer
- 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl)
- Preservative
- 0.2% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:1000 - 1:2000
Target
- Alternative Names
- ST1; MDA9; SYCL; MDA-9; TACIP18
- Gene ID
- 6386
- UniProt ID
- O00560
- Long Name
- Syndecan Binding Protein
- Cellular Localization
- Cell junction; Cell membrane; Cytoplasm; Cytoskeleton; Endoplasmic reticulum; Membrane; Nucleus; Secreted
- Post Translation Modifications
- Acetylation; Phosphoprotein
- Protein Refseq
- NP_001007068.1
- Function
- Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527).; Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292).; In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).; Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120).; In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591).; May also play a role in vesicular trafficking (PubMed:11179419).; Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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