Recombinant Mouse Anti-SDCBP Antibody (VS4-CJ109)
CAT#: VS4-CJ109
This mouse anti-SDCBP antibody is a product that recognizes human, dog, rat, porcine SDCBP. The immunogen of this antibody is a purified recombinant human SDCBP protein fragment expressed in E. coli. The mAb has been tested for use in ELISA, Western Blot (1:500-1:5000).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, nuclear membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong positivity in peripheral nerves.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human vulva/anal skin
Immunohistochemical staining of human vulva/anal skin shows distinct cytoplasmic positivity in melanocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nuclear membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/241_E2_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 5 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nuclear membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/239_E2_1_red_green.jpg
Normal Tissue
Figure 6 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_8_5.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_7_3.jpg
Normal Tissue
Figure 8 Skin
Epidermal cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_5_8.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (HHSteC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137575-SDCBP
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Specifications
- Immunogen
- Purified recombinant human SDCBP protein fragments expressed in E. coli.
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human, Dog, Rat, Porcine SDCBP
- Species Reactivity
- Human, Dog, Rat, Porcine
- Applications
- ELISA, WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.1M Tris-Glycine (150 mM NaCl), pH 7.4.
- Preservative
- 0.2% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000).
Target
- Alternative Names
- ST1; MDA9; SYCL; MDA-9; TACIP18
- Gene ID
- 6386
- UniProt ID
- O00560
- Long Name
- Syndecan binding protein
- Cellular Localization
- Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus, Secreted
- Post Translation Modifications
- Phosphorylated on tyrosine residues.
- Protein Refseq
- NP_001007068.1; NP_001007069.1; NP_001007070.1
- Function
- Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527).
Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292).
In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).
Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120).
In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591).
May also play a role in vesicular trafficking (PubMed:11179419).
Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
See other products for "SDCBP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1089-VHH | Recombinant Anti-human SDCBP VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3191 | Hi-Affi™ Recombinant Rabbit Anti-SDCBP Monoclonal Antibody (DS3191AB) | WB, IHC, ICC, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1465-CN | Recombinant Rabbit Anti-SDCBP Monoclonal Antibody (JE40-72) | WB, IF, IHC, FC, IP | Rabbit IgG |
| VS3-WK345 | Rabbit Anti-SDCBP Recombinant Antibody (clone JE40-72) | WB, ELISA | Rabbit IgG |
| VS4-CJ108 | Recombinant Mouse Anti-SDCBP Antibody (clone 2A3E2) | ELISA, WB | Mouse IgG2b |
| VS7-0425-WR834 | Mouse Anti-SDCBP Recombinant Antibody (VS7-0425-WR834) | WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2012 | Anti-SDCBP Immunohistochemistry Kit | IHC | |
| VS-0525-XY6408 | Anti-Mouse SDCBP Immunohistochemistry Kit | IHC | |
| VS-0525-XY6407 | Anti-Human SDCBP Immunohistochemistry Kit | IHC |
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