Recombinant Anti-ST14 Vesicular Antibody, EV Displayed (VS-0425-YC304)
CAT#: VS-0425-YC304
The Recombinant Anti-ST14 Vesicular Antibody, EV Displayed (VS-0425-YC304) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ST14-expressed cells or tissues. The ST14 is a serine protease involved in epithelial cell morphogenesis, linked to conditions like Sjogren's syndrome and congenital ichthyosis.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47014/1549_C6_1_selected.jpg
Normal Tissue
Figure 2 Testis
Cells in seminiferous ducts
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56258/131283_A_6_6.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CACO-2, CAPAN-2, HaCaT, OE19, RPMI-8226, SK-BR-3, T-47d, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000149418-ST14/subcellular
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ST14
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ST14 transmembrane serine protease matriptase
- Molecular Function
- Hydrolase, Protease, Serine protease
- Cellular Localization
- Nucleoplasm, Vesicles
- Introduction
- Enables serine-type endopeptidase activity. Involved in proteolysis. Acts upstream of or within epithelial cell morphogenesis involved in placental branching and neural tube closure. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase).
- Alternative Names
- Epithin, MT-SP1, Prss14, Tmprss14, mCAP3, matriptase
- Gene ID
- 19143
- UniProt ID
- P56677
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| TAB-0731CL-S(P) | Anti-Human ST14 Recombinant Antibody scFv Fragment (M32) | ELISA |
| CAT | Product Name | Application | Type |
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| TAB-0732CL-S(P) | Human Anti-ST14 Recombinant Antibody; scFv Fragment (TAB-0732CL-S(P)) | ELISA, IHC, FC | Human scFv |
| CAT | Product Name | Application | Type |
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| TAB-0731CL-F(E) | Anti-Human ST14 Recombinant Antibody Fab Fragment (M32) | ELISA |
| CAT | Product Name | Application | Type |
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| TAB-0732CL-F(E) | Human Anti-ST14 Recombinant Antibody; Fab Fragment (TAB-0732CL-F(E)) | ELISA, IHC, FC | Human Fab |
| CAT | Product Name | Application | Type |
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| VS-0224-XY123 | Mouse Anti-ST14 Recombinant Antibody (VS-0224-XY123) | ELISA, WB, IF, IP, IHC-P | Mouse IgG1 |
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