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ST14
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Distal enterocytes, Paneth cells, Urothelial cells, Proximal enterocytes, Undifferentiated cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Cell line enhanced (CACO-2, CAPAN-2, HaCaT, OE19, RPMI-8226, SK-BR-3, T-47d, U-698)
Interaction
Interacts with CDCP1. May interact with TMEFF1.
Molecular function
Hydrolase, Protease, Serine protease
More Types Infomation
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, IF, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, IF, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG
- Application: WB, IF, FuncS
- Recombinant Human Anti-human ST14 Antibody Fab Fragment (MHH-923-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: Neut, IF, FuncS
- Recombinant Anti-human ST14 Antibody scFv Fragment (MOB-923-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, Neut, Biosensors, FuncS
- Recombinant Anti-human ST14 Antibody Fab Fragment (MOB-923-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, IP, FuncS
- Recombinant Anti-human ST14 Antibody (MOB-923)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: Neut, IF, FuncS
- Recombinant Human Anti-human ST14 Antibody scFv Fragment (MHH-923-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: RIA, ELISA, FuncS
- Mouse Anti-ST14 Recombinant Antibody (VS-0224-XY123) (VS-0224-XY123)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IF, IP, IHC-P
- Mouse Anti-ST14 Antibody (clone M32), mRNA (TAB-0731CL-mRNA)
-
- Species Reactivity: Human
- Human Anti-ST14 Recombinant Antibody; Fab Fragment (TAB-0732CL-F(E)) (TAB-0732CL-F(E))
-
- Species Reactivity: Mouse
- Type: Human Fab
- Application: ELISA, IHC, FC
- Anti-Human ST14 Recombinant Antibody Fab Fragment (M32) (TAB-0731CL-F(E))
-
- Application: ELISA
- Human Anti-ST14 Recombinant Antibody (TAB-0732CL) (TAB-0732CL)
-
- Species Reactivity: Mouse
- Type: Human IgG
- Application: ELISA, IHC, FC
- Anti-Human ST14 Recombinant Antibody (M32) (TAB-0731CL)
-
- Application: ELISA, WB
- Human Anti-ST14 Recombinant Antibody; scFv Fragment (TAB-0732CL-S(P)) (TAB-0732CL-S(P))
-
- Species Reactivity: Mouse
- Type: Human scFv
- Application: ELISA, IHC, FC
- Anti-Human ST14 Recombinant Antibody scFv Fragment (M32) (TAB-0731CL-S(P))
-
- Application: ELISA
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For Research Use Only. Not For Clinical Use.