Human Anti-ST14 Recombinant Antibody (clone A11) (CAT#: PABL-661)
Recombinant Human Antibody (A11) is capable of binding to MT-SP1, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-MT-SP1 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-MT-SP1 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody was identified with a 720 pM inhibition constant and high specificity for matriptase over other trypsin-fold serine proteases.
Specific Inquiry
Figure 1 Antibodies are specific for active MT-SP1.
SPR binding curves of MT-SP1 (black) and the zymogen-like mutant R15A (gray) to the A11 Fab show robust binding to active enzyme and a lack of binding to the zymogen, indicating that the inhibitor is specific for the active form of the enzyme. Binding assays with enzyme concentrations up to 1 μmol/L showed similar results (not shown). RU, resonance unit.
Darragh, M. R., Schneider, E. L., Lou, J., Phojanakong, P. J., Farady, C. J., Marks, J. D., ... & Craik, C. S. (2010). Tumor detection by imaging proteolytic activity. Cancer research, 0008-5472.
Specifications
- Immunogen
- Human suppression of tumorigenicity 14 (colon carcinoma)
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG
- Specificity
- Human ST14
- Species Reactivity
- Human
- Clone
- A11
- Applications
- WB, IF, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- ST14; suppression of tumorigenicity 14 (colon carcinoma); HAI; MTSP1; SNC19; ARCI11; MT-SP1; PRSS14; TADG15; TMPRSS14; suppressor of tumorigenicity 14 protein; prostamin; serine protease 14; serine protease TADG-15; membrane-type serine protease 1; tumor associated differentially expressed gene 15 protein; tumor-associated differentially-expressed gene 15 protein; suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
- Gene ID
- 6768
- UniProt ID
- Q9Y5Y6
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-923 | Recombinant Anti-human ST14 Antibody | WB, IP, FuncS | IgG |
| MHH-923 | Recombinant Human Anti-human ST14 Antibody | Neut, IF, FuncS | IgG |
| VS-0224-XY123 | Mouse Anti-ST14 Recombinant Antibody (VS-0224-XY123) | ELISA, WB, IF, IP, IHC-P | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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