Human Anti-ST14 Recombinant Antibody (clone A11) (CAT#: PABL-661)
Recombinant Human Antibody (A11) is capable of binding to MT-SP1, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-MT-SP1 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-MT-SP1 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody was identified with a 720 pM inhibition constant and high specificity for matriptase over other trypsin-fold serine proteases.
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Figure 1 Antibodies are specific for active MT-SP1.
SPR binding curves of MT-SP1 (black) and the zymogen-like mutant R15A (gray) to the A11 Fab show robust binding to active enzyme and a lack of binding to the zymogen, indicating that the inhibitor is specific for the active form of the enzyme. Binding assays with enzyme concentrations up to 1 μmol/L showed similar results (not shown). RU, resonance unit.
Darragh, M. R., Schneider, E. L., Lou, J., Phojanakong, P. J., Farady, C. J., Marks, J. D., ... & Craik, C. S. (2010). Tumor detection by imaging proteolytic activity. Cancer research, 0008-5472.
Specifications
- Immunogen
- Human suppression of tumorigenicity 14 (colon carcinoma)
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG
- Specificity
- Human ST14
- Species Reactivity
- Human
- Clone
- A11
- Applications
- WB, IF, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- ST14; suppression of tumorigenicity 14 (colon carcinoma); HAI; MTSP1; SNC19; ARCI11; MT-SP1; PRSS14; TADG15; TMPRSS14; suppressor of tumorigenicity 14 protein; prostamin; serine protease 14; serine protease TADG-15; membrane-type serine protease 1; tumor associated differentially expressed gene 15 protein; tumor-associated differentially-expressed gene 15 protein; suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
- Gene ID
- 6768
- UniProt ID
- Q9Y5Y6
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-923 | Recombinant Anti-human ST14 Antibody | WB, IP, FuncS | IgG |
| MHH-923 | Recombinant Human Anti-human ST14 Antibody | Neut, IF, FuncS | IgG |
| VS-0224-XY123 | Mouse Anti-ST14 Recombinant Antibody (VS-0224-XY123) | ELISA, WB, IF, IP, IHC-P | Mouse IgG1 |
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