Recombinant Mouse Anti-VHL Antibody (clone 3B1-8B7-4H3)
CAT#: VS3-FY1545
This product is a recombinant mouse antibody that recognizes VHL. This antibody has been reported for use in Immunohistochemistry-Paraffin. The clone 3B1-8B7-4H3 is specific for human VHL. The antigen is synthetic peptides derived from human pvhl.
Gene Expression
Tested Data
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31631/723_F1_2_selected.jpg
❮
❯
IHC-P
Figure 1. Recombinant Mouse Anti-VHL Antibody (clone 3B1-8B7-4H3) in IHC-P.
Immunohistochemical analysis of paraffin-embedded Kindey using VHL antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
❮
❯
Specifications
- Immunogen
- Synthetic peptides derived from human pVHL.
- Host Species
- Mouse
- Type
- Mouse IgG3
- Specificity
- Human VHL
- Species Reactivity
- Human
- Clone
- 3B1-8B7-4H3
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS, pH 7.3, 50% glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry-Paraffin: 1/100-1/500
Target
- Alternative Names
- Von Hippel-Lindau Tumor Suppressor; Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase; Protein G7; PVHL; Von Hippel-Lindau Disease Tumor Suppressor; Von Hippel-Lindau Syndrome
- Gene ID
- 7428
- UniProt ID
- P40337
- Sequence Similarities
- Belongs to the VHL family.
- Cellular Localization
- Cytoplasm, Membrane, Nucleus
- Protein Refseq
- NP_000542.1; NP_937799.1
- Function
- Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS3-FY1545. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "VHL"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2116CT | Recombinant Mouse anti-Human VHL Monoclonal antibody (4G402) | IHC-P, WB | |
| MOB-0233F | Mouse Anti-VHL Recombinant Antibody (MOB-0233F) | IHC-P, IF | Mouse IgG |
| MOB-0234F | Mouse Anti-VHL Recombinant Antibody (MOB-0234F) | IHC-P, IF | Mouse IgG |
| VS3-CJ927 | Mouse Anti-VHL Recombinant Antibody (clone PT0230) | IHC-P | Mouse IgG3, κ |
| VS3-CJ928 | Mouse Anti-VHL Recombinant Antibody (clone ABT-PVHL) | IHC-P | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2469 | Anti-VHL Immunohistochemistry Kit | IHC | |
| VS-0525-XY7848 | Anti-Mouse VHL Immunohistochemistry Kit | IHC | |
| VS-0525-XY7847 | Anti-Human VHL Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, Neut
Application: ELISA, WB
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, IHC, FC, Cyt, ELISA
Application: Neut, ELISA, FuncS
Application: ELISA, IP, WB, IHC, IF, FuncS
Application: ELISA, Inhib, FuncS
Application: ELISA, IHC, IF, IP, FC, FuncS
Application: ELISA, WB
Application: ELISA, Neut
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, IHC, FC, Cyt, ELISA
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
