Recombinant Mouse Anti-VHL Antibody (clone 3B1-8B7-4H3) (CAT#: VS3-FY1545)
This product is a recombinant mouse antibody that recognizes VHL. This antibody has been reported for use in Immunohistochemistry-Paraffin. The clone 3B1-8B7-4H3 is specific for human VHL. The antigen is synthetic peptides derived from human pvhl.
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IHC-P
Figure 1. Recombinant Mouse Anti-VHL Antibody (clone 3B1-8B7-4H3) in IHC-P.
Immunohistochemical analysis of paraffin-embedded Kindey using VHL antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
Specifications
- Immunogen
- Synthetic peptides derived from human pVHL.
- Host Species
- Mouse
- Type
- Mouse IgG3
- Specificity
- Human VHL
- Species Reactivity
- Human
- Clone
- 3B1-8B7-4H3
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS, pH 7.3, 50% glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry-Paraffin: 1/100-1/500
Target
- Alternative Names
- Von Hippel-Lindau Tumor Suppressor; Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase; Protein G7; PVHL; Von Hippel-Lindau Disease Tumor Suppressor; Von Hippel-Lindau Syndrome
- Gene ID
- 7428
- UniProt ID
- P40337
- Sequence Similarities
- Belongs to the VHL family.
- Cellular Localization
- Cytoplasm, Membrane, Nucleus
- Protein Refseq
- NP_000542.1; NP_937799.1
- Function
- Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
Recommended Products
Secondary Antibody
Isotype Control
Reconstitution Buffer
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4018z | Mouse Anti-VHL Recombinant Antibody (clone 38G11) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| MOB-0233F | Mouse Anti-VHL Recombinant Antibody (MOB-0233F) | IHC-P, IF | Mouse IgG |
| MOB-0234F | Mouse Anti-VHL Recombinant Antibody (MOB-0234F) | IHC-P, IF | Mouse IgG |
| VS3-CJ927 | Mouse Anti-VHL Recombinant Antibody (clone PT0230) | IHC-P | Mouse IgG3, κ |
| VS3-CJ928 | Mouse Anti-VHL Recombinant Antibody (clone ABT-PVHL) | IHC-P | Mouse IgG2b, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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