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ABO

This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene.
Protein class

Metabolic proteins

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Proximal enterocytes, Undifferentiated cells, Intestinal goblet cells, Granulosa cells)

Immune cell specificity

Immune cell enhanced (naive B-cell, eosinophil)

Cell line specificity

Cell line enhanced (CAPAN-2, HaCaT, K-562, OE19, RT4)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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