Recombinant Anti-ABO Intrabody [(D-Arg)9] (CAT#: IAB-B061(A))
Recombinant anti-ABO intrabody linked to (D-Arg)9 works within cells to bind AbO, expressed in CHO cells. The anti-AbO intrabody selectively intercepts critical AbO conformers and controls their "toxic" assembly in the ER, without interfering with the complex processes of maturation and processing of APP.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (CAPAN-2, HaCaT, K-562, OE19, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000175164-ABO
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000175164-ABO
Specifications
- Immunogen
- Alzheimer's amyloid beta oligomers
- Host Species
- mouse
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Applications
- Used for immunoassay techniques such as: Immunofluorescence; Flow Cytometry; Functional studies
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- ABO; Alzheimer's amyloid beta oligomers
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-27 | Recombinant Anti-human ABO Antibody | WB, Neut, FuncS | IgG |
| MHH-27 | Recombinant Human Anti-human ABO Antibody | ELISA, IP, FuncS | IgG |
| MOB-2273MZ | Mouse Anti-ABO Recombinant Antibody (clone 0B) | ELISA, IP | Mouse IgG3 |
| VS13-YC8 | Rabbit Anti-ABO Recombinant Antibody (VS13-YC8) | WB, IP | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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