Recombinant Anti-ABO Intrabody [Tat] (CAT#: IAB-B061(T))
Recombinant anti-ABO intrabody in fusion with HIV Tat works within cells to bind AbO, expressed in CHO cells. The anti-AbO intrabody selectively intercepts critical AbO conformers and controls their "toxic" assembly in the ER, without interfering with the complex processes of maturation and processing of APP.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (CAPAN-2, HaCaT, K-562, OE19, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000175164-ABO
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000175164-ABO
Specifications
- Immunogen
- Alzheimer's amyloid beta oligomers
- Host Species
- mouse
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Applications
- Can be useful in applications such as: Western blot; Immunocytochemistry; Neutralization; Functional studies
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Target
- Alternative Names
- ABO; Alzheimer's amyloid beta oligomers
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ABO"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-27 | Recombinant Anti-human ABO Antibody | WB, Neut, FuncS | IgG |
| MHH-27 | Recombinant Human Anti-human ABO Antibody | ELISA, IP, FuncS | IgG |
| MOB-2273MZ | Mouse Anti-ABO Recombinant Antibody (clone 0B) | ELISA, IP | Mouse IgG3 |
| FAMAB-0112JF | Human Anti-ABO Recombinant Antibody (clone BT97) | WB, ELISA, IHC | Human IgM, λ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-27-F(E) | Recombinant Anti-human ABO Antibody Fab Fragment | RIA, ELISA, FuncS | Fab |
| MHH-27-F(E) | Recombinant Human Anti-human ABO Antibody Fab Fragment | IP, Neut, FuncS | Fab |
| FAMAB-0112JF-F(E) | Human Anti-ABO Recombinant Antibody (clone BT97); Fab Fragment | FC, WB, ELISA, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-27-S(P) | Recombinant Anti-human ABO Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| MHH-27-S(P) | Recombinant Human Anti-human ABO Antibody scFv Fragment | WB, FC, FuncS | scFv |
| FAMAB-0112JF-S(P) | Human Anti-ABO Recombinant Antibody (clone BT97); scFv Fragment | FC, WB, ELISA, FuncS | Human scFv |
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B061(A) | Recombinant Anti-ABO Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B061(G) | Recombinant Anti-ABO Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0024 | Hi-Affi™ Rabbit Anti-ABO Recombinant Antibody (clone DS24AB) | WB, IP | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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