ACHE

Blood group antigen proteins, Enzymes, FDA approved drug targets, Metabolic proteins

Intracellular, Membrane (different isoforms)

Cell type enhanced (Paneth cells, Distal enterocytes, Horizontal cells, Proximal enterocytes, Exocrine glandular cells, Erythroid cells)

Not detected in immune cells

Cell line enhanced (BEWO, CACO-2, K-562, Karpas-707, U-2 OS)

Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric.

Blood group antigen, Hydrolase, Serine esterase