Recombinant Anti-ACHE Vesicular Antibody, EV Displayed (VS-0425-YC444)
CAT#: VS-0425-YC444
The Recombinant Anti-ACHE Vesicular Antibody, EV Displayed (VS-0425-YC444) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ACHE-expressed cells or tissues. The ACHE is acetylcholinesterase, terminating cholinergic signaling and influencing conditions linked to synapse function and blood group antigen.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line MCF7 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27098/1502_G3_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (BEWO, CACO-2, K-562, Karpas-707, U-2 OS)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000087085-ACHE
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ACHE
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Acetylcholinesterase (Cartwright blood group)
- Biological Process
- Neurotransmitter degradation
- Molecular Function
- Blood group antigen, Hydrolase, Serine esterase
- Cellular Localization
- Golgi apparatus, Vesicles
- Introduction
- Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.
- Alternative Names
- YT
- Gene ID
- 43
- UniProt ID
- P22303
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Datasheet
MSDS
COA
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|---|---|---|---|
| MHH-31-S(P) | Recombinant Human Anti-human ACHE Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| PSBL-004 | Mouse Anti-ACHE Recombinant Antibody (clone Ab408); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-004 | Mouse Anti-ACHE Recombinant Antibody (clone Ab408) | WB, ELISA, FuncS | Mouse IgG |
| PABL-024 | Recombinant Mouse Anti-BfAChE Antibody (mAb410) | WB, ELISA, FuncS | IgG |
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| VS-0423-XY7 | Mouse Anti-AChE Recombinant Antibody (clone AE-2) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-004 | Mouse Anti-ACHE Recombinant Antibody (clone Ab408); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| PFBL-024 | Recombinant Mouse Anti-BfAChE Antibody Fab Fragment (mAb410) | WB, ELISA, FuncS | Fab |
| PFBL-374 | Mouse Anti-ACHE Recombinant Antibody (clone Fab408); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| PFBL-375 | Recombinant Mouse Anti-BfAChE Antibody Fab Fragment (Fab410) | WB, ELISA, FuncS | Fab |
| PFBZ-040 | Recombinant Mouse Anti-Electric eel AChE Antibody Fab Fragment (mAb408) | BL | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-004CQ | Mouse Anti-ACHE Recombinant Antibody (clone ZR3) | Block, IF, IHC, IP | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3945 | Hi-Affi™ Rabbit Anti-ACHE Recombinant Antibody (clone SI5DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-002CN | Human Anti-ACHE Recombinant Antibody (clone PD-c-hASP) | WB, ELISA, FC, IP | Human IgG |
| NS-002CN-F(E) | Human Anti-ACHE Recombinant Antibody (clone PD-c-hASP); Fab Fragment | WB, ELISA, FC, IP | Human Fab |
| NS-002CN-S(P) | Human Anti-ACHE Recombinant Antibody (clone PD-c-hASP); scFv Fragment | WB, ELISA, FC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY74 | Anti-ACHE Immunohistochemistry Kit | IHC | |
| VS-0525-XY75 | Anti-Mouse ACHE Immunohistochemistry Kit | IHC |
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