Anti-CBX5 Products

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For Research Use Only. Not For Clinical Use.

As a frontrunner in epigenetics and chromatin biology research, Creative Biolabs is proud to present its premium anti-CBX5 recombinant antibodies. Heterochromatin Protein 1 Alpha (HP1-alpha), the “reader” protein that identifies and binds to heterochromatin, is a master of chromosome organization. Encoded by the CBX5 gene, it is a non-histone chromosomal protein. Our superior quality antibodies are the perfect tools for researching gene silencing, genomic stability, and cancer and aging-related epigenetic alterations.

CBX5: The Heterochromatin Protein 1 Alpha (HP1α)

The Chromobox Protein Homolog 5 (CBX5) gene encodes the Heterochromatin Protein 1 Alpha (HP1α) which is one of the basic non-histone chromosomal proteins. HP1α is a structural component of heterochromatin (dense and transcriptionally inactive region of the genome). It is an epigenetic “reader.” HP1α has a chromodomain that specifically binds to histone H3 when it is trimethylated at lysine 9 (H3K9me3), a classical epigenetic mark for silent chromatin. HP1α then recruits proteins that compact the chromatin and ensure that genes remain off. This is crucial to genome integrity and stable repression of genes, for example, transposable elements.

Alternative Names

HP1; HP1A; HEL25; chromobox protein homolog 5; HP1 alpha homolog; HP1-ALPHA; HP1Hs alpha; antigen p25; chromobox homolog 5 (HP1 alpha homolog, Drosophila); epididymis luminal protein 25; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha

Background

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Anti-CBX5 rAb Products

Creative Biolabs anti-CBX5 recombinant antibodies are designed for optimal performance. The rAbs are extensively validated to specifically detect the HP1α protein. Optimized for use in ChIP-seq to map heterochromatin domains genome-wide, immunofluorescence to visualize heterochromatic foci, and Western Blot, our rAbs are the ultimate epigenetics research tool.
Table 1. Featured anti-CBX5 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is committed to providing customers with the highest quality reagents. The production of our anti-CBX5 recombinant antibodies is rigorously controlled by a comprehensive quality assurance system. Lots are extensively tested for purity, specificity to other HP1 isoforms, and consistent performance for ChIP and immunofluorescence.

Customer Reviews

rAb Production

Creative Biolabs is on a mission to help move epigenetics research forward by using state-of-the-art antibody production technologies. Our recombinant antibodies for CBX5 are produced with advanced technologies and extensive screening to ensure they offer the affinity and specificity needed for tough applications like ChIP-seq.

Featured Anti-CBX5 Recombinant Antibody Production Platforms
Fig.4 Milligram-scale anti-CBX5 recombinant antibody production.

Fig.5 Gram-scale anti-CBX5 recombinant antibody production.

rAb Modalities

Creative Biolabs has a deep commitment to providing the research community with flexible and innovative tools. Our anti-CBX5 antibodies are available in multiple formats and formulations optimized for a variety of chromatin research applications.

Fig.6 Full-length anti-CBX5 recombinant antibody production and modalities.

Move forward with your epigenetics research with Creative Biolabs’ high-quality, elite anti-CBX5 recombinant antibodies. Our portfolio of chromatin research tools is built on a foundation of unrivaled performance in chromatin applications and extensive validation, ensuring that you have access to the ideal tools for studying genome organization. Allow us to support your important work. Contact our experts today.