Anti-CCNA2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your partner in cell cycle and oncology research with our premium anti-CCNA2 recombinant antibodies. As the central regulatory subunit of the cell cycle machine, Cyclin A2 (CCNA2) is a major driver of S-phase and mitosis. Our top-quality antibodies provide researchers with an optimal tool to study cell proliferation and tumor growth and predict cancer prognosis.

CCNA2: The Key Driver of the S/G2/M Transition

Cyclin A2 (CCNA2) is part of a family of regulatory proteins that control the progression of the eukaryotic cell cycle. CCNA2 is crucial because it binds and activates both Cyclin-Dependent Kinase 2 (CDK2) and Cyclin-Dependent Kinase 1 (CDK1) at different stages of the cell cycle. The Cyclin A2-CDK2 complex promotes entry into S-phase (DNA synthesis) and early G2. The Cyclin A2-CDK1 complex then promotes entry into mitosis (M-phase). As the expression of CCNA2 is tightly restricted to the S, G2, and M phases, it is an accurate biomarker of actively proliferating cells. High CCNA2 expression is also often associated with a poor prognosis in various cancers.

Alternative Names

Cyclin A2; Cyclin-A; CCN1; CCNA; Cyclin-A2; Cyclin A;

Background

CCNA2 (Cyclin A2) is a Protein Coding gene. Splenic Diffuse Red Pulp Small B-Cell Lymphoma and Valproate Embryopathy are the diseases that are associated with CCNA2. Some of the pathways that this gene overlaps are CDK-mediated phosphorylation and removal of Cdc6 and Signaling events mediated by PRL. The gene ontology (GO) annotations that overlap with this gene include protein kinase binding. A significant paralog of this gene is CCNA1.

Anti-CCNA2 rAb Products

Creative Biolabs’ anti-CCNA2 recombinant antibodies are designed for high specificity and robust performance. They are rigorously validated to ensure accurate detection of the CCNA2 protein. Optimized for applications including Western Blot to study cell cycle synchronization, IHC to determine proliferation in tumor samples (marker of aggressive growth) and immunofluorescence, our rAbs are of the highest quality tools for cell cycle research.
Table 1. Featured anti-CCNA2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs leverages cutting-edge production platforms to meet the unique needs of oncology research. Our anti-CCNA2 recombinant antibodies are expressed in optimized systems to ensure they recognize the native protein of interest with high specificity and activity.

Featured Anti-CCNA2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CCNA2 recombinant antibody production.

Fig.2 Gram-scale anti-CCNA2 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to empowering your research with flexible antibody solutions. Creative Biolabs anti-CCNA2 recombinant antibodies are available in multiple modalities to fit your experimental needs, enabling scientists across the world to study this important regulator of the cell cycle.

Fig.3 Full-length anti-CCNA2 recombinant antibody production and modalities.

Use the best reagents for your cell cycle research with Creative Biolabs’ high-quality anti-CCNA2 recombinant antibodies. Defined by unmatched specificity and thorough validation, our portfolio is comprised of the best tools for your research into cell proliferation and cancer prognosis. Our expertise is the foundation you can rely on for your research. Get in touch with our experts today.