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CD38

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The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, Dot, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
Neut, WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, Neut, FuncS
Targets:
CD38 & saporin
Type:
F(ab')2
Application:
FuncS, Pretargeting system for immunotoxin delivery
Targets:
CD59 & CD38
Type:
CrossMab
Application:
FuncS, Promising therapeutic agent
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, ELISA, FuncS
Type:
Human antibody
Application:
FC
Derivation:
Phage display library
Species Reactivity:
Cynomolgus
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Phage display library
Species Reactivity:
Cynomolgus
Type:
Human antibody
Application:
ELISA, FC
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Target:
CD38
Species Reactivity:
Human
Cytokine 1:
IFNα
Host:
human
Cytokine 1 Species:
Human
Molecule Class:
L kappa; IgG1-IFNα
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Type:
Human antibody
Application:
FC
Derivation:
Phage display library
Species Reactivity:
Cynomolgus
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Phage display library
Species Reactivity:
Cynomolgus
Type:
Human antibody
Application:
ELISA, FC
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