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CD38

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In humans, the CD38 protein is encoded by the CD38 gene located on chromosome 4. CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes, and natural killer cells. CD38 also plays a role in cell adhesion, signal transduction and calcium signaling. CD38 is a multifunctional extracellular enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. Loss of CD38 function is associated with impaired immune responses, metabolic disorders, and behavioral changes, including social autism that may be associated with autism. The CD38 protein is a hallmark of cell activation. It is associated with HIV infection, leukemia, myeloma, solid tumors, type 2 diabetes and bone metabolism and some genetically determined conditions. In addition, CD38 produces enzymes that regulate the release of oxytocin in the central nervous system. Daratumumab (trade name Darzalex) is an anti-cancer drug. It combines CD38. Daratumumab was originally developed by Genmab but is now jointly developed by Genmab and Janssen Biotech, a Johnson & Johnson company. In 2013, Daratumumab achieved breakthrough therapeutic status for multiple myeloma.

Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IP, IF, FuncS, FC, Neut, ELISA, IHC
Targets:
CD38 & saporin
Type:
F(ab')2
Application:
FuncS, Pretargeting system for immunotoxin delivery
Targets:
CD59 & CD38
Type:
CrossMab
Application:
FuncS, Promising therapeutic agent
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Type:
Human antibody
Application:
FC
Derivation:
Phage display library
Species Reactivity:
Cynomolgus
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Phage display library
Species Reactivity:
Cynomolgus
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Phage display library
Species Reactivity:
Cynomolgus
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Phage display library
Species Reactivity:
Cynomolgus
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Phage display library
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, Dot, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
Neut, WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, Neut, FuncS
Species Reactivity:
Mouse
Type:
Llama VHH
Application:
WB, IHC, FC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA
Type:
Human antibody
Application:
FC
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